Enantioselective Synthesis of Optically Active Bis(β-hydroxy) Sulfones through Asymmetric Hydrogenation of Corresponding Ketones Catalyzed by a Chiral Cationic Ruthenium Diamine Catalyst  

作　　者：Xiaofei Huang Min Zhao Naikai Li Haiyan Li Jie Li Xingwang Wang 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry and Chemical Engineering,Suzhou University,Suzhou,Jiangsu,215123 China [2]Shanghai Institute of Measurement and Testing Technology,Shanghai 201203,China

出　　处：《Chinese Journal of Chemistry》2014年第8期803-813,共11页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(No.21272166);the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.13KJA150004);the Program for New Century Excellent Talents in University(No.NCET-12-0743).

摘　　要：Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β-hydroxy)sulfones catalyzed by a chiral cationic ruthenium diamine catalyst.A series of bis(β-hydroxy)sulfones have been obtained in excellent yields(up to 99%)with excellent enantioselectivities(up to 99%)as well as good diastereoselectivities(up to 99∶1).

关 键 词：asymmetric catalysis hydrogenation RUTHENIUM SULFONE 1 5-diol 

分 类 号：O62[理学—有机化学]