A Highly Enantioselective Mannich-Type Reaction of Glycine Schiff Base Catalyzed by a Cinchoninium Salt  

作　　者：Zhonglin Tao Arafate Adele Xiang Wu Liuzhu Gong 

机构地区：[1]Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry,University of Science and Technology of China,Hefei,Anhui 230026,China

出　　处：《Chinese Journal of Chemistry》2014年第10期969-973,共5页中国化学（英文版）

基　　金：We are grateful for financial support from the National Natural Science Foundation of China(No.21232007).

摘　　要：A chiral phase-transfer catalyst,derived from the combination of cinchona alkaloid backbone and BINOL skeleton,enabled a Mannich reaction of glycine Schiff base with N-Boc-imines to generateα,β-diamino acid derivatives in excellent yields(up to 99%)and with high diastereo-and enantioselectivities(up to>20∶1 dr,96%ee).

关 键 词：phase-transfer catalysis Mannich reaction α β-diamino acid asymmetric catalysis cinchoninium salt 

分 类 号：O62[理学—有机化学]