Synthesis and Structure of Azacalix[2]pyrimidine[2]triazines and Their Self-assembly in the Solid State  

作　　者：Lixia Wang Dexian Wang Meixiang Wang 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,Key Laboratory for Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences,Beijing,100190,China [2]Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology,Department of Chemistry,Tsinghua University,Beijing 100084,China

出　　处：《Chinese Journal of Chemistry》2014年第10期1033-1038,共6页中国化学（英文版）

基　　金：We thank the National Natural Science Foundation of China(Nos.21132005,21121004);the Ministry of Science and Technology of China(Nos.2011CB932501,2013CB834504)for financial support.

摘　　要：A number of azacalix[2]pyrimidine[2]triazines were synthesized in moderate to good yields from both a step-wise fragment coupling approach and a one-pot reaction strategy starting from 4,6-diaminopyrimidines and cyanuric chloride.Nucleophilic aromatic substitution reaction of resulting dichloro-substituted azacalix[2]-pyrimidine[2]triazines with NH_(4)Cl led to the formation of NH_(2)-bearing azacalix[2]pyrimidine[2]triazine analogs.Azacalix[2]pyrimidine[2]triazines adopted symmetric 1,3-alternate conformations in solution while twisted 1,3-alternate conformations were observed in the solid state.In the presence of different additives during the growth of single crystals,azacalix[2]pyrimidine[2]triazines containing amino(-NH_(2))groups gave varied self-assembled structures due to the formation of different intermolecular hydrogen bond motifs.

关 键 词：pyrimidine[2]triazine fragment coupling approach one-pot reaction SELF-ASSEMBLY hydrogen bond 

分 类 号：O62[理学—有机化学]