An Efficient and Simple Method for Stereoselective Synthesis of N-Substituted Iminosugars from D-Xylose Derivative  

作　　者：Jichao Zhang Wen Yuan Xiaofeng Ma Haibo Wang Huawu Shao 

机构地区：[1]Natural Products Research Center,Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2014年第4期361-364,共4页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.21372215 and 20972151).

摘　　要：A series of new N-substituted iminosugars were successfully synthesized through a general synthetic route from D-xylose derivative.This approach provided a convenient access to the synthesis of N-alkylated iminosugars as po-tential glucosidase inhibitors,which included a reaction of reductive amination.Various N-alkylated iminosugars were prepared in good yields with high stereoselectivity.

关 键 词：IMINOSUGARS stereoselective synthesis N-ALKYLATION reductive amination Michael addition 

分 类 号：O76[理学—晶体学]