犬利什曼病不同临床表现与血液指标变化的相关性  

Correlation between different clinical manifestations and changes of blood indexes in canine leishmaniasis

作　　者：余大为[1] 李凡[1] 冯宇[1] 杨成明[1] 杨俊克[1] 朱亚东 Yu Dawei;Li Fan;Feng Yu;Yang Chengming;Yang Junke;Zhu Yadong(Department for Parasitic Disease Prevention and Control,Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730020,China)

机构地区：[1]甘肃省疾病预防控制中心寄生虫病防制科,兰州730020

出　　处：《中华地方病学杂志》2023年第8期623-626,共4页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81703171);甘肃省中医药科研课题(GZKP-2022-31)。

摘　　要：目的了解甘肃省内脏利什曼病高发区不同临床症状利什曼原虫感染犬的主要血液参数,为犬利什曼病的早期诊断和病情监测提供科学依据。方法2019年5月,选取甘肃省内脏利什曼病历史疫区陇南市文县和甘南藏族自治州迭部县为调查现场,以PCR检测利什曼原虫DNA阳性的40只犬为调查对象,根据其临床症状分为无症状(n=17)、少症状(n=12)和多症状(n=11)3组,同时选取10只健康犬作为对照。利用动物全自动血液五分类细胞分析仪进行主要血液指标检测。结果与对照组相比,无症状、少症状和多症状组的红细胞数量、血红蛋白含量、血细胞比容、淋巴细胞数量、单核细胞数量、嗜酸性粒细胞数量均减少(均P<0.05),少症状和多症状组白细胞、中性粒细胞数量均减少(均P<0.05);且上述血液指标,多症状组均低于无症状组(均P<0.05)。其中红细胞数量(对照组比多症状组)由(6.82±0.05)×10^(12)个/L降为(4.19±0.08)×10^(12)个/L、血红蛋白含量由(15.84±0.74)g/L降为(9.65±0.18)g/L、血细胞比容由(46.41±0.95)%降为(27.86±0.42)%、白细胞数量由(14.90±0.22)×10^(9)个/L降为(10.23±0.24)×10^(9)个/L、中性粒细胞数量由(7.25±0.18)×10^(9)个/L降为(6.18±0.11)×10^(9)个/L、淋巴细胞数量由(2.80±0.07)×10^(9)个/L降为(1.64±0.06)×10^(9)个/L、单核细胞数量由(1.13±0.01)×10^(9)个/L降为(0.53±0.02)×10^(9)个/L、嗜酸性粒细胞数量由(1.70±0.06)×10^(9)个/L降为(0.71±0.03)×10^(9)个/L。结论不同临床症状利什曼原虫感染犬血液指标检测结果不同。Objective To study the main blood parameters of Leishmania-infected dogs with different clinical symptoms in the high incidence area of visceral leishmaniasis in Gansu Province,and to provide scientific basis for early diagnosis and monitoring of canine leishmaniasis.Methods In May 2019,Wenxian County of Longnan City and Diebu County of Gannan Tibetan Autonomous Prefecture,the historical endemic areas of visceral leishmaniasis in Gansu Province,were selected as the investigation sites,and 40 dogs with positive Leishmania DNA were investigated.According to their clinical symptoms,they were divided into three groups:asymptomatic(n=17),minimally symptomatic(n=12)and symptomatic(n=11).At the same time,10 healthy dogs were selected as controls.Major blood indexes were detected by an automatic animal blood five-classification cell analyzer.Results Compared with the control group,the number of red blood cells,hemoglobin content,hematocrit,and the number of lymphocytes,monocytes and eosinophils in the asymptomatic,minimally symptomatic and symptomatic groups were decreased(P<0.05),while the number of white blood cells and neutrophils in minimally symptomatic and symptomatic groups were decreased(P<0.05).The above blood indexes were lower in the symptomatic group than those in the asymptomatic group.The number of red blood cells(control group vs symptomatic group)decreased from(6.82±0.05)×10^(12)/L to(4.19±0.08)×10^(12)/L,hemoglobin content decreased from(15.84±0.74)g/L to(9.65±0.18)g/L,hematocrit decreased from(46.41±0.95)%to(27.86±0.42)%,the number of white blood cells decreased from(14.90±0.22)×10^(9)/L to(10.23±0.24)×10^(9)/L,the number of neutrophils decreased from(7.25±0.18)×10^(9)/L to(6.18±0.11)×10^(9)/L,the number of lymphocytes decreased from(2.80±0.07)×10^(9)/L to(1.64±0.06)×10^(9)/L,the number of monocytes decreased from(1.13±0.01)×10^(9)/L to(0.53±0.02)×10^(9)/L,and the number of eosinophils decreased from(1.70±0.06)×10^(9)/L to(0.71±0.03)×10^(9)/L.Conclusion Different clinical sym

关 键 词：犬科 婴儿利什曼原虫 血液学 无症状感染 

分 类 号：R531.6[医药卫生—内科学] S858.292[医药卫生—临床医学]