微动刺激幅值对骨组织与钛珠涂层界面的骨生长与微损伤的影响  

Effects of Fretting Stimulation Amplitude on Bone Growth and Micro-Injury at the Interface Between Bone Tissues and Titanium Bead Coating

作　　者：闫东 张德坤[1] 冯存傲 陈凯[1] 赵玉洁 YAN Dong;ZHANG Dekun;FENG Cunao;CHEN Kai;ZHAO Yujie(School of Materials Science and Physics,China University of Mining and Technology,Xuzhou 221116,Jiangsu,China)

机构地区：[1]中国矿业大学材料与物理学院,江苏徐州221116

出　　处：《医用生物力学》2023年第3期528-534,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(51875564)。

摘　　要：目的通过微动力学刺激改善人工关节生物固定界面的性能。方法以活性大鼠骨组织与非活性钛珠涂层的结合试样作为研究对象,利用自制的微动力学刺激试验装置,探究不同切向微动幅值的力学刺激对固定界面骨组织生长促进作用及骨组织微损伤的影响,揭示微动刺激下骨组织在钛珠涂层表面的促进生长与微损伤机制。结果微动幅值为40μm力学刺激组骨组织与钛珠涂层间的界面结合力最大,切向摩擦力-位移曲线由椭圆形转变为直线形,结合界面处于黏着区,不易产生松动,骨组织结构最完整,钛珠涂层表面黏附生长的组织细胞数量最多,分布范围最广。随着微动幅值的增加,微动刺激对骨生长的促进作用减弱,骨组织与钛珠涂层界面间结合强度逐渐降低,内部空腔区域增多,组织细胞的数量及增殖活性也有不同程度的降低。结论不同幅值微动刺激对于骨组织的生长促进与微损伤同时存在,最优的微动幅值为40μm。Objective To improve the performance of artificial joint at biological fixed interface by fretting mechanical stimulation.Methods Taking the bonding sample of active rat bone tissues and inactive titanium bead coating as the research object,by using the self-developed fretting mechanical stimulation test device,the effects of mechanical stimulation with different tangential fretting amplitudes on growth promotion and micro-injury of bone tissues at fixed interface were explored,and the mechanism of growth promotion and micro-injury of bone tissues on the surface of titanium bead coating under fretting stimulation was revealed.Results The mechanical stimulation group with 40μm fretting amplitude showed the maximum interface bonding force between bone tissues and titanium bead coating.The tangential fraction force-displacement curves changed from elliptic shape to linear shape,and the bonding interface was in adhesion area,which was difficult to become loose.The bone tissues had the most complete structure,and the number of tissue cells adhering and growing on the surface of titanium bead coating was the largest,as well as the distribution range was the widest.With the increase of fretting amplitude,the promoting effect of fretting stimulation on bone growth weakened,the bonding strength between bone tissues and titanium bead coating interface gradually decreased,the internal cavity area increased,the number and proliferation activity of tissue cells decreased to varying degrees as well.Conclusions Fretting stimulation with different amplitudes can promote the growth of bone tissue and cause micro-injury at the same time,and the optimal fretting amplitude is 40μm.

关 键 词：微动刺激 钛珠涂层 微动幅值 生物固定界面 骨生长 微损伤 

分 类 号：R318.01[医药卫生—生物医学工程]