用于颈动脉风险评估的生物力学参数研究综述  

Biomechanical Parameters for Carotid Risk Assessment:A Review

作　　者：杨宇恒 任淑琪 陈增胜[1] 樊瑜波[1] 孙安强[1] 邓小燕[1] YANG Yuheng;REN Shuqi;CHEN Zengsheng;FAN Yubo;SUN Anqiang;DENG Xiaoyan(Beijing Advanced Innovation Center for Biomedical Engineering,Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China)

机构地区：[1]北京航空航天大学生物与医学工程学院、生物力学与力生物学教育部重点实验室、北京市生物医学工程高精尖创新中心,北京100083

出　　处：《医用生物力学》2023年第3期615-620,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11872096,12172033,32071311)。

摘　　要：颈动脉由于其特殊的几何构型以及复杂的流动特性,具有较高的动脉粥样硬化发生风险,各类生物力学参数是对颈动脉进行患病风险评估的有力工具。振荡的低剪切应力环境促进斑块形成这一观点已被广泛接受,以此为基础,越来越多的力学指标被提出,例如时均壁面剪切力、剪切振荡系数和相对滞留时间等。本文对剪切力及其时空变化、湍流、血小板运输及活化和血管壁应力集中等生物力学参数进行介绍,并分析颈动脉风险评估相关生物力学参数研究的发展趋势,可为更全面、快速的颈动脉风险评估提供理论基础。Carotid is in a high risk of atherosclerosis due to its special geometric features and complex flow characteristics.Various biomechanical parameters are practical tools for carotid risk assessment.It has been widely accepted that oscillatory low shear environment promotes plaque formation.Based on this,more and more biomechanical indexes have been proposed,such as time-average wall shear stress,oscillatory shear index,relative residence time and so on.In this paper,multiple biomechanical parameters were introduced from the perspectives of shear stress and its temporal and spatial variation,turbulence,platelet transport and activation,stress concentration in vascular wall,etc.The development trend of biomechanical parameters related to carotid artery risk assessment was also analyzed,so as to provide the theoretical basis for more comprehensive and rapid carotid risk assessment.

关 键 词：颈动脉 动脉粥样硬化 计算模拟 

分 类 号：R318.01[医药卫生—生物医学工程]