茯苓对小鼠胃肠动力调节作用的研究  

Effect of poria cocos on gastrointestinal motility in mice

作　　者：冯敏 郏自明[1] 万鸣 樊柏林[1] 唐晓荞[1] 程文华[1] 孙凡中[1] FENG Min;JIA Ziming;WAN Ming;FAN Bolin;TANG Xiaoqiao;CHENG Wenhua;SUN Fanzhong(Hubei Provincial Key Laboratory of Applied Toxicology,Hubei Provincial Center for Disease Control and Prevention,Wuhan,Hubei 430075,China)

机构地区：[1]湖北省疾病预防控制中心应用毒理湖北省重点实验室,湖北武汉430075

出　　处：《公共卫生与预防医学》2023年第5期39-41,共3页Journal of Public Health and Preventive Medicine

基　　金：国家重点研发计划项目(No.2017YFC1703005)。

摘　　要：目的 探讨茯苓对小鼠胃肠动力的调节作用。方法 将130只昆明小鼠随机分为阴性对照组,生茯苓粉低、高剂量组,熟茯苓粉低、高剂量组,茯苓代培粉低、高剂量组,茯苓水提物低、中、高剂量组,茯苓醇提物低、中、高剂量组,每组10只,连续灌胃给药7 d, 1次/d。末次给药后,通过肠推进功能试验和胃固体排空试验,观察茯苓对小鼠胃肠动力的调节作用。结果 与阴性对照组比较,代培粉低剂量组小肠推进率显著升高(P<0.01),除生茯苓粉高剂量组外,其余各茯苓组均有较高的胃残留率(P<0.05)。结论 茯苓对正常生理状态小鼠的肠推进无明显促进作用,但可抑制正常小鼠胃排空,对小鼠的胃肠功能具有缓和作用。Objective To investigate the regulatory effect of poria cocos on gastrointestinal motility in mice.Methods A total of 130 Kunming mice were randomly divided into negative control group,low-dose and high-dose groups of raw poria cocos powder,low-dose and high-dose groups of cooked poria cocos powder,low-dose and high-dose groups of poria cocos surrogate culture powder,low-dose,medium-dose and high-dose groups of poria cocos water extract,and low-dose,medium-dose and high-dose groups of poria cocos alcohol extract,with 10 mice in each group.The animals were administered by gavage for 7 days,once a day.After the last administration,the intestinal propulsion function test and gastric solid emptying test were conducted to observe the regulating effect of poria cocos on gastrointestinal motility of mice.Results Compared with the negative control group,the small intestine propulsion rate in the low-dose group of poria cocos surrogate culture powder was significantly increased(P<0.01).Except the high-dose group of raw poria cocos powder,the other poria cocos groups had higher gastric residual rate(P<0.05).Conclusion Poria cocos does not promote intestinal propulsion of mice under normal physiological condition,but it can inhibit gastric empting and exert a moderating effect on gastrointestinal function in normal mice.

关 键 词：茯苓 小鼠 胃肠动力 推进率 

分 类 号：R114[医药卫生—卫生毒理学]