艾灸对弥漫大B细胞淋巴瘤化疗患者骨髓抑制的影响  

Effect of moxibustion on myelosuppression in patients receiving chemotherapy for diffuse large B-cell lymphoma

作　　者：陈丽红[1] 单坤生 陈雅铃 杨雪容 王玮[1] CHEN Lihong;SHAN Kunsheng;CHEN Yaling;YANG Xuerong;WANG Wei(No.909 Hospital of People’s Liberation Army of China(Southeast Hospital Affiliated to Xiamen University),Zhangzhou 363000,China)

机构地区：[1]联勤保障部队第九〇九医院(厦门大学附属东南医院),漳州363000

出　　处：《上海针灸杂志》2023年第9期895-899,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：全军医药卫生科研项目(15MS108)。

摘　　要：目的观察艾灸对弥漫大B细胞淋巴瘤化疗患者骨髓抑制、集落刺激因子水平和中医证候积分的影响。方法回顾性分析联勤保障部队第九〇九医院收治的126例弥漫大B细胞淋巴瘤化疗患者,随机分为艾灸预治疗组(41例)、艾灸治疗组(44例)和对照组(41例)。3组均予化疗,艾灸预治疗组于化疗开始前7 d进行艾灸,每日1次,共14 d;艾灸治疗组于化疗开始时进行艾灸,每日1次,共7 d;对照组行常规化疗。比较3组治疗前后白细胞(white blood cell,WBC)计数、中性粒细胞(neutrophil,NEU)计数、血红蛋白(haemoglobin,Hb)、血小板(platelet,PLT)计数、粒细胞-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)水平、粒细胞集落刺激因子(granulocyte colony-stimulating factor,G-CSF)水平、骨髓抑制分度及中医证候积分的变化。结果治疗后,对照组和艾灸治疗组WBC计数、NEU计数、Hb和PLT计数低于艾灸预治疗组(P<0.05);对照组低于艾灸治疗组(P<0.05)。3组治疗后骨髓抑制分度比较差异有统计学意义(P<0.05)。对照组和艾灸治疗组治疗后GM-CSF和G-CSF水平低于艾灸预治疗组(P<0.05),对照组低于艾灸治疗组(P<0.05)。对照组治疗后重组人G-CSF使用率高于艾灸治疗组和艾灸预治疗组(P<0.05)。对照组和艾灸治疗组治疗后中医证候积分高于艾灸预治疗组(P<0.05);对照组高于艾灸治疗组(P<0.05)。结论艾灸对弥漫大B细胞淋巴瘤化疗患者骨髓抑制具有积极作用。Objective To observe the effects of moxibustion on myelosuppression,colony-stimulating factor level,and symptom scores of traditional Chinese medicine(TCM)in patients undergoing chemotherapy for diffuse large B-cell lymphoma.Method A retrospective analysis was conducted amongst 126 patients receiving chemotherapy for diffuse large B-cell lymphoma admitted to No.909 Hospital of People’s Liberation Army of China.The cases were randomized into a pre-moxibustion group(41 cases),a moxibustion group(44 cases),and a control group(41 cases).Chemotherapy was offered to all three groups.In addition,the pre-moxibustion group started to receive moxibustion 7 d before chemotherapy,once daily for 14 d;the moxibustion group started to receive moxibustion concurrently with chemotherapy,once daily for 7 d;the control group only received the conventional chemotherapy.Before and after the treatment,white blood cell(WBC)count,neutrophil(NEU)count,haemoglobin(Hb),platelet(PLT)count,granulocyte-macrophage colony-stimulating factor(GM-CSF)level,granulocyte colony-stimulating factor(G-CSF)level,myelosuppression degree,and TCM symptom scores were compared.Result After the treatment,the WBC count,NEU count,Hb,and PLT count were lower in the control and moxibustion groups than in the pre-moxibustion group(P<0.05),and the control group was lower than the moxibustion group(P<0.05);there were significant differences in the myelosuppression degree amongst the three groups after the treatment(P<0.05);the GM-CSF and G-CSF levels were lower in the control and moxibustion groups than in the pre-moxibustion group(P<0.05),and the control group was lower than the moxibustion group(P<0.05);the recombinant human G-CSF consumption rate was higher in the control group than in the moxibustion and pre-moxibustion groups(P<0.05);the TCM symptom scores were higher in the control and moxibustion groups than in the pre-moxibustion group(P<0.05),and the control group was higher than the moxibustion group(P<0.05).Conclusion Moxibustion can produce positive eff

关 键 词：灸法 间接灸 温灸器灸 淋巴瘤 大B细胞 弥漫性 化疗 骨髓抑制 

分 类 号：R246.5[医药卫生—针灸推拿学]