针药并用治疗儿童过敏性鼻炎-哮喘综合征的疗效观察及对FeNO、FEV_(1)%、PEF的影响  

Observation of the effect of acupuncture combined with medication on children with allergic rhinitis and asthma syndrome and its influence on FeNO,FEV_(1)% and PEF

作　　者：丁丽凤[1] 刘尽美 张皓[1] DING Lifeng;LIU Jinmei;ZHANG Hao(Shanghai Children’s Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心,上海200127

出　　处：《上海针灸杂志》2023年第9期939-943,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：上海市科委中医引导类科研计划项目(17401931100);上海市卫健委科研计划项目(ZHYY-ZXYJHZX-202022)。

摘　　要：目的观察针药并用治疗儿童过敏性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndrome,CARAS)的临床疗效及对呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)、1秒率[第1秒用力呼气容积(forced expiratory volume in the first second,FEV_(1))/用力肺活量(forced vital capacity,FVC)]、呼气峰流速(peak expiratory flow,PEF)的影响。方法将90例CARAS患者随机分3组,每组30例。对照1组采用沙美特罗替卡松气雾剂联合孟鲁司特钠治疗,对照2组采用针刺治疗,治疗组采用针刺联合沙美特罗替卡松气雾剂及孟鲁司特钠治疗。观察3组治疗前后中医证候积分、FeNO、FEV_(1)/FVC和PEF的变化,并比较3组临床疗效。结果治疗组临床疗效明显优于对照1组和对照2组(P<0.05)。治疗后,3组中医证候积分低于治疗前(P<0.05),治疗组中医证候积分治疗前后差值明显高于对照1组和对照2组(P<0.05);3组FeNO水平均降低(P<0.05),且治疗组低于对照1组和对照2组(P<0.05);3组FEV_(1)%及PEF水平均升高(P<0.05),且治疗组高于对照1组和对照2组(P<0.05)。结论针药并用可有效改善CARAS患者的气道炎症与肺功能,缓解症状与体征,临床疗效良好。Objective To observe the clinical efficacy of acupuncture combined with medication in the treatment of combined allergic rhinitis and asthma syndrome(CARAS)in children and its effect on fractional exhaled nitric oxide(exhaled nitric oxide,FeNO),forced expiratory volume in the first second[(FEV_(1))/forced vital capacity(FVC),FEV_(1)/FVC]and peak expiratory flow(PEF).Method A total of 90 patients with CARAS were randomly divided into three groups,with 30 cases in each group.The control group 1 was treated with salmeterol fluticasone aerosol combined with montelukast sodium,the control group 2 was treated with acupuncture,and the treatment group was treated with acupuncture combined with salmeterol fluticasone aerosol and montelukast sodium.The changes of TCM syndrome score,FeNO,FEV_(1)/FVC and PEF were observed before and after treatment,and the clinical efficacy was compared among the three groups.Result The clinical efficacy of the treatment group was significantly better than that of the control group 1 and control group 2(P<0.05).After treatment,the TCM syndrome score of the three groups were lower than those before treatment(P<0.05),and the difference of TCM syndrome score before and after treatment in the treatment group was significantly higher than that in the control group 1 and the control group 2(P<0.05).The FeNO levels in the three groups were decreased(P<0.05),and they were lower in the treatment group than in the control group 1 and control group 2(P<0.05).The levels of FEV_(1)%and PEF in the three groups were increased(P<0.05),and those in the treatment group were higher than those in the control group 1 and control group 2(P<0.05).Conclusion The combination of acupuncture and medication can effectively improve airway inflammation and lung function in patients with CARAS,relieve symptoms and signs,and has good clinical effect.

关 键 词：针药并用 过敏性鼻炎-哮喘综合征 呼吸超敏反应 炎症 儿童 

分 类 号：R246.4[医药卫生—针灸推拿学]