Notch信号通路在活动性类风湿关节炎中的作用  

Role of Notch signaling pathway in active rheumatoid arthritis

作　　者：程增玉 徐浩东 唐晓颇(指导)[1] CHENG Zengyu;XU Haodong;TANG Xiaopo(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国免疫学杂志》2023年第9期1965-1969,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(81873281);国家重点研发计划项目(2018YFC1705200)。

摘　　要：Notch信号通路在细胞发育、分化、凋亡等方面扮演重要角色,对免疫疾病也发挥广泛的调控作用。类风湿关节炎(RA)的病理特征包括滑膜炎和血管翳,反复发作的活动性RA可致成、破骨细胞失衡,形成骨破坏。研究发现Notch信号在活动性RA中影响滑膜样成纤维细胞增殖与迁移、巨噬细胞释放炎症因子、血管新生、骨破坏等多项病理环节,是RA治疗的重要靶点。综述近二十年Notch信号通路在活动性RA中作用的研究进展。Notch signaling pathway plays an important role in cell development,differentiation,apoptosis,it also plays a broad regulatory role in immune diseases.The pathological features of rheumatoid arthritis(RA)include synovitis and pannus.Recurrent active RA can cause an imbalance between osteoblasts and osteoclasts,and ultimately lead to bone destruction.Studies have found that Notch signaling affects the proliferation and migration of synovial fibroblasts,the release of inflammatory factors from macrophages,angiogenesis,and bone destruction in active RA.It is an important target for RA treatment.This review summarizes the research progress of Notch signaling pathway in active RA in the past two decades.

关 键 词：类风湿关节炎 NOTCH信号 综述 

分 类 号：R593.22[医药卫生—内科学]