The protection of CoronaVac against the infection of wild-type SARS-CoV-2(WH-09)or Omicron variant in nude-hACE2 mice  

作　　者：Kaili Lin Meixuan Liu Lu Sun Hanjun Fu Hongwei Qiao Shunyi Wang Sidan Pan Hong Gao 

机构地区：[1]Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China

出　　处：《Animal Models and Experimental Medicine》2023年第4期346-354,共9页动物模型与实验医学（英文）

基　　金：the National Key Research and Development Project of China,Grant/Award Number:2020YFA0707600。

摘　　要：Background:Immunocompromised individuals have an increased risk of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and severe outcomes,but we pay less attention to these people.Athymic nude mice are a murine strain with a spontaneous deficiency of the Foxn1 gene,which can result in thymic degeneration or its absence,leading to immunosuppression and a decrease in the number of T cells,and are widely used in preclinical evaluations of disease in immunocompromised populations.Methods:We investigated the protection of the coronavirus disease 2019(COVID-19)inactivated vaccine(CoronaVac)against the infection of wild-type SARS-CoV-2(WH-09)or Omicron variant utilizing a hybrid-type nude-hACE2 mouse model.Results:Compared with nude-hACE2/W mice,the viral load in the brain and lung tissue of nude-hACE2 mice(nude-hACE2/WV)infected with WH-09 after vaccination significantly decreased,and the histopathological changes were also reduced.The viral load in the brain and lung tissue of nude-hACE2 mice(nude-hACE2/OV)infected with the Omicron variant after vaccination was lower than that in nude-hACE2/O,but histopathological symptoms did not improve significantly.Conclusion:CoronaVac provides some protection against infection of both WH-09 and the Omicron variant in the nude-hACE2 mice.Our findings aimed to provide a reference for vaccination against SARS-CoV-2 in immunocompromised populations.

关 键 词：IMMUNOCOMPROMISED nude-hACE2 mice PROTECTION severe acute respiratory syndrome coronavirus 2 

分 类 号：R563.1[医药卫生—呼吸系统]