原发性高血压患者baPWV与PRC、PAC、ARR的相关性研究  

Correlation between baPWV and PRC,PAC,ARR in Patients with Essential Hypertensive

作　　者：易春秀 赵雅静 郭子宏 YI Chunxiu;ZHAO Yajing;GUZihong(The Affiliated Criorascular Disease Hospital of Kunming Medical Uniersiy(Fuwai Yunnan Cardiorascular Hopitial),Yunnan 650032,China)

机构地区：[1]云南省阜外心血管病医院高血压病区,昆明650032

出　　处：《医学研究杂志》2023年第8期136-139,共4页Journal of Medical Research

基　　金：云南省心血管病临床医学中心项目(FZX2019-06-01)。

摘　　要：目的探讨原发性高血压(essential hypertension,EH)患者臂踝脉搏波传导速度(brachial and ankle pulse wave conduction velocity,baPWV)与血浆肾素浓度(plasmaren in concentration,PRC)、血浆醛固酮浓度(plasma aldosterone concentration,PAC)及醛固酮/肾素(aldosterone to renin ratio,ARR)的相关性。方法随机收集2021年3~4月参与云南省安宁市“中国居民心血管病及其危险因素监测”项目的研究对象208例,根据有无EH将研究对象分为非EH组和EH组,分别采集两组的基本资料、血生化、PRC、PAC、ARR及baPWV等指标。采用Spearman相关性分析评价EH患者baPWV与PRC、PAC、ARR的相关性。结果两组体重指数(bogymass index,BMI)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、PRC、ARR、baPWV比较,差异均有统计学意义。Spearman相关性分析结果显示,baPWV与PRC(r=-0.148,P=0.131)、PAC(r=0.095,P=0.333)均无相关性,而baPWV与ARR(r=0.095,P=0.027)呈正相关。结论EH患者baPWV与PRC、PAC无显著相关性,与ARR呈正相关,ARR可作为动脉粥样硬化的预测指标和影响因素。Objective To explore the correlation between brachial and ankle pulse wave conduction velocity(baPWV)and plasma renin concentration(PRC),plasma aldosterone concentration(PAC),aldosterone to renin ratio(ARR)in patients with essential hypertension(EH).Methods A total of 208 subjects participating in the project of"Monitoring of Cardiovascular Disease and its Risk Factors"in Anning city,Yunnan province from March to April 2021 were randomly collected,they were divided into non-EH group and EH group according to whether EH was present or not.The basic information,blood biochemical,PRC,PAC,ARR and baPWV indicators of the two groups were collected respectively.Spearman correlation analysis was used to analyze the correlation between baPWV and PRC,PAC,ARR in EH patients.Results There were significant differences in the bogy mass index(BMI),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),PRC,ARR between the two groups.Spearman correlation analysis showed that baPWV was not correlated with PRC PRC(r=-0.148,P=0.131)and PAC(r=0.095,P=0.333),while baPWVwas positively correlated with ARR(r=0.095,P=0.027).Conclusion There was no significant correlation between baPWV and PRC,PAC in EH patients,but was positively correlated with ARR,and ARR can be used as a predictor and influencing factor of atherosclerosis.

关 键 词：原发性高血压 脉搏波传导速度 肾素 醛固酮 

分 类 号：R543.5[医药卫生—心血管疾病]