围术期应用抗生素降低开腹胆石症患者术后伤口感染率的效果  

Perioperative Application of Antibiotics to Reduce the Rate of Postoperative Wound Infection in Patients with Open Cholelithiasis

作　　者：曾凡剑[1] 吴岑江 唐楹[1] 黎坚[1] 高妍[1] Zeng Fanjian;Wu Cenjiang;Tang Ying;Li Jian;Gao Yan(Hepatobiliary Surgery Department of Wuzhou Red Cross Hospital,Wuzhou 543002,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西梧州市红十字会医院肝胆外科,广西壮族自治区梧州543002

出　　处：《中外医药研究》2023年第10期9-11,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20200043)。

摘　　要：目的:探讨围术期应用抗生素降低开腹胆石症患者术后伤口感染率的作用。方法:选取2016年1月—2020年12月在广西梧州市红十字会医院行开腹胆总管探查T管引流术患者121例为治疗组[围术期使用哌拉西林钠他唑巴坦钠(TZP)],以2011年5月—2015年6月收治的行相同术式患者100例为对照组(围术期使用三代头孢类抗生素)。比较两组患者术后伤口感染率、乙级愈合率、二期清创缝合率。结果:治疗组伤口感染率低于对照组,差异有统计学意义(P=0.008);两组伤口乙级愈合率比较,差异无统计学意义(P>0.05);治疗组伤口二期清创缝合率低于对照组,差异有统计学意义(P<0.001)。结论:对于行开腹胆石症患者,围术期使用TZP治疗可以较好地预防伤口感染,降低伤口感染率及伤口二期清创缝合率。Objective:To investigate the effect of perioperative application of antibiotics on reducing postoperative wound infection rate in patients with open Gallstone.Methods:A total of 121 patients who underwent open common bile duct exploration and T-tube drainage in Wuzhou Red Cross Hospital of Guangxi Province from January 2016 to December 2020 were selected as the treatment group[Piperacillin tazobactam(TZP)was used in the perioperative period].A total of 100 patients treated from May 2011 to June 2015 who underwent the same operation were selected as the control group(third-generation cephalosporins antibiotics were used in the perioperative period).The postoperative wound infection rate,grade B healing rate and secondary debridement and suture rate were compared between the two groups.Result:The wound infection rate in the treatment group was significantly lower than that in the control group,and the difference was statistically significant(P=0.008);there was no statistically significant difference in the grade B wound healing rate between the two groups(P>0.05);The rate was lower than that of the control group,and the difference was statistically significant(P<0.001).Conclusion:Perioperative TZP treatment can better prevent wound infection,reduce the rate of wound infection and the rate of secondary wound debridement and suture for patients with open Gallstone.

关 键 词：胆石症 伤口感染 抗生素 围术期 

分 类 号：R65[医药卫生—外科学]