血小板相关指标检测在煤工尘肺患者中的临床应用效果  

Clinical Application of Platelet Related Index Detection in Coal Workers Pneumoconiosis Patients

作　　者：钟待鸣 Zhong daiming(Hunan Occupational Disease Prevention and Control Institute,Changsha 410007,Hunan Province,China)

机构地区：[1]湖南省职业病防治院,湖南长沙410007

出　　处：《中外医药研究》2023年第10期115-117,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨血小板相关指标检测对煤工尘肺(CWP)患者的临床应用效果。方法:选取2021年2月—2023年2月湖南省职业病防治院收治的CWP患者546例为研究组,同期278名健康体检者为对照组,根据研究组患者病情分为单纯尘肺(SP)组(251例)与进行性大规模纤维化(PMF)组(295例)2个亚组,对所有受试者进行血小板相关指标检测。比较研究组和对照组以及研究组中2个亚组的血小板相关指标[血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)]水平,并以Spearman相关性分析血小板相关指标与病程的相关性。结果:研究组PLT、MPV、PCT、PDW水平高于对照组,差异有统计学意义(P<0.001);SP组PLT、MPV、PCT、PDW水平低于PMF组,差异有统计学意义(P<0.001);Spearman相关性分析结果显示,PLT、MPV、PCT、PDW水平与患者病情程度呈正相关(r=0.716,P<0.001)。结论:血小板相关指标可作为CWP患者的病程指标,临床上可根据患者病程及早进行干预,以预防CWP病情加重。Objective:To explore the clinical application effect of platelet related detection in coal workers pneumoconiosis(CWP)patients.Methods:A total of 546 CWP patients were selected as the research group at the Hunan Provincial Occupational Disease Prevention and Control Institute from February 2021 to February 2023,and 278 healthy subjects during the same period were selected as the control group.They were divided into a simple pneumoconiosis(SP)group(251 cases)and the progressive massive fibrosis(PMF)group(295 cases)in the research group according to the condition of the patients,platelet-related indicators were detected for all subjects.The levels of platelet-related indicators[platelet count(PLT),mean platelet volume(MPV),platelet packing(PCT),platelet distribution width(PDW)]of the research group,control group and two subgroups were compared,and the correlation between platelet-related and disease course was analyzed by the Spearman.Results:The levels of PLT,MPV,PCT,and PDW of the research group were higher than those of the control group,and the differences were statistically significant(P<0.001);the levels of PLT,MPV,PCT,and PDW of the SP group were lower than those of the PMF group,and the differences were statistically significant(P<0.001);Spearman correlation analysis showed that the levels of PLT,MPV,PCT,and PDW were positively correlated with the disease severity of patients(r=0.716,P<0.001).Conclusion:Platelet-related can be used as indicators of disease course in CWP patients,and early intervention can be performed according to the course of disease to prevent the exacerbation of CWP.

关 键 词：煤工尘肺 血小板相关指标 单纯尘肺 进行性大规模纤维化 

分 类 号：R13[医药卫生—劳动卫生]