2018-2021年北京市某区腹泻病例中沙门菌主要型别与耐药特征分析  

Major serotypes and antibiotic resistance phenotype of Salmonellain patients with diarrhea in a district of Beijing, 2018—2021

作　　者：王会波[1] 张爽[1,2] 李颖[1,2] 康颖 闫爱霞 王凤双[1] 彭涛[1] WANG Huibo*;ZHANG Shuang;LI Ying;KANG Ying;YAN Aixia;WANG Fengshuang;PENG Tao(Shunyi District Center for Disease Control and Prevention,Beijing 101300,China)

机构地区：[1]北京市顺义区疾病预防控制中心质量管理科,北京101300 [2]北京市顺义区疾病预防控制中心微生物感染性疾病检测工作站

出　　处：《中国预防医学杂志》2023年第7期653-656,共4页Chinese Preventive Medicine

摘　　要：目的 分析北京市某区腹泻病例分离沙门菌主要型别与耐药特征。方法 收集2018—2021年北京市某区腹泻病例粪便样本并进行沙门菌培养、鉴定和血清分型,同时进行14种抗生素敏感性检测。结果2018—2021年该区腹泻病例中沙门菌检出率为4.96%(54/1 089),共分离出55株沙门菌,包括19种血清型,构成比最高为肠炎沙门菌(45.45%,25/55)。55株沙门菌对链霉素、氨苄西林、萘啶酸耐药率分别为60.00%、58.18%、58.18%;25株肠炎沙门菌对萘啶酸、链霉素、氨苄西林耐药率分别为96.00%、80.00%、76.00%。结论 优势血清型为肠炎沙门菌,血清型变化和耐药表型特征发生变化,沙门菌对亚胺培南中介耐药率的提高,提示本地区应加强对碳青霉烯类抗生素规范使用和院感监测。Objective To analyze the major serotypes and antibiotic resistance phenotype of Salmonella isolated from patients with diarrhea in a district of Beijing.Methods A total of 1089 stool samples from diarrhea patients between 2018—2021 in a district in Beijing were collected for Salmonella culture,identification and serotyping.Antibiotic resistance test was performed for 14 antibiotics.Results The detection rate of Salmonella was 4.96%(54/1089)among the diarrhea patients in the study area in the period 2018—2021,and a total of 55 strains of Salmonella were isolated,including 19 serotypes,of which S.Enteritidis was the dominant serotype(45.45%,25/55).Of the 55 strains,60.00%,58.18%,and 58.18%were resistant to streptomycin,ampicillin,and nalidixic acid,respectively;and 96.00%,80.00%,and 76.00%of the 25 S.Enteritidis strains were resistant to streptomycin,ampicillin,and nalidixic acid,respectively.Conclusion The dominant serotype of Salmonella is S.Enteritidis,with changes in serotype distribution and drug resistance phenotype characteristics.The increase of imipenem resistance in Salmonella suggests that standardized use of carbapenem antibiotics and monitoring of hospital-acquired infection should be strengthened in the study region.

关 键 词：沙门菌 腹泻 培养法 血清型 抗生素耐药 

分 类 号：R183.1[医药卫生—流行病学]