2005-2018年宁波市慢性阻塞性肺疾病疾病负担分析  

Disease burden of chronic obstructive pulmonary disease inNingbo, 2005—2018

作　　者：冯伟 李辉[2] 王永[2] 李思萱[2] 陆蓓蓓[2] 纪威[2] 刘世炜[3] FENG Wei;LI Hui;WANG Yong;LI Sixuan;LU Beibei;JI Wei;LIU Shiwei(Fenghua District Center for Disease Control and Prevention,Ningbo,Zhejiang 315010,China)

机构地区：[1]宁波市奉化区疾病预防控制中心,浙江宁波315000 [2]宁波市疾病预防控制中心 [3]中国疾病预防控制中心

出　　处：《中国预防医学杂志》2023年第7期668-672,共5页Chinese Preventive Medicine

基　　金：国家重点研发计划(2018YFC1315300)。

摘　　要：目的 估计2005—2018年宁波市慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的疾病负担和变化趋势,为制定有针对性的COPD防控策略提供依据。方法 采用2005—2018年宁波市户籍居民死因监测数据计算过早死亡导致的损失生命年(years of life lost,YLL),利用社会人口指数和YLL拟合模型间接计算伤残导致的损失生命年(years lived with disability,YLD),分析COPD导致的疾病负担伤残调整生命年(disability-adjusted life years,DALY)。利用Excel 2013软件整理数据并计算YLL、YLD和DALY标化率。利用Joinpoint 4.9.0.0软件计算相关指标的年度变化百分比(annual percent change,APC)。结果 2005—2018年宁波市COPD的标化YLL率和标化DALY率呈下降趋势。标化DALY率由2005的2 122.34/10万下降到2018年1 327.82/10万(APC=-3.27%,P<0.05),男性标化DALY率高于女性。YLL是DALY的主要组成部分,2005—2018年宁波市YLL在DALY占比为66.25%~79.74%。结论 2005—2018年宁波市COPD疾病负担总体呈下降趋势,但仍不可忽视,应重点关注男性人群COPD的早期筛查与干预,减少因COPD死亡导致的疾病负担。Objective To estimate the disease burden and secular trend of chronic obstructive pulmonary disease(COPD)in Ningbo in the period from 2005 to 2018,so as to provide evidence for formulating targeted strategies for COPD prevention and control.Methods Death surveillance data in Ningbo during 2005—2018 were used to calculate the years of life lost(YLL).The years lived with disability(YLD)was indirectly calculated using the socio-demographic index and YLL/YLD ratio,and the disability-adjusted life year(DALY)caused by COPD were estimated.Excel 2013 was used for data processing and calculating the standardized YLL,YLD and DALY.The annual percent change(APC)of relevant indexes was calculated with Joinpoint 4.9.0.0.Results From 2005 to 2018,the standardized YLL and DALY rates of COPD in Ningbo showed a downward trend.The standardized DALY rate decreased from 2122.34/100000 in 2005 to 1327.82/100000 in 2018(APC=−3.27%,P<0.05).The standardized DALY rate of males was higher than that of females.YLL was the main component of DALY.From 2005 to 2018,YLL accounted for 66.25%-79.74%of DALY in Ningbo.Conclusions From 2005 to 2018,the disease burden of COPD in Ningbo showed an overall downward trend,but it is still unignorable.Attention should be paid to the early screening and intervention of COPD in the male population,thus to reduce the disease burden caused by death from COPD.

关 键 词：慢性阻塞性肺疾病 疾病负担 伤残调整生命年 

分 类 号：R563[医药卫生—呼吸系统]