先天性巨结肠肠道微环境异常及其临床转化潜能  

Intestinal microenvironment abnormalities of Hirschsprung disease and its potential clinical transformation

作　　者：余辉[1] 潘伟康[1] 高亚[1] Yu Hui;Pan Weikang;Gao Ya(Department of Pediatric Surgery,Second Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院小儿外科,西安710004

出　　处：《中华小儿外科杂志》2023年第8期752-758,共7页Chinese Journal of Pediatric Surgery

基　　金：国家自然科学基金(82071692,82170531);西安交通大学临床-基础融合项目(YXJLRH2022053);陕西省重点研发计划(2022SF-133/033);国家留学基金委(202006285023)。

摘　　要：细胞移植是根治先天性巨结肠的潜在策略,但目前遭遇多种瓶颈,迫切需要"追根溯源"提高再认识水平。除神经节缺失、外源性神经纤维代偿性肥大增粗之外,先天性巨结肠还存在多种肠道微环境的异常。本综述拟从先天性巨结肠存在的多种肠道微环境异常着手,探寻其中"蕴含"具有神经再生潜能的施万前体细胞以及肠道微环境代谢产物短链脂肪酸、胶质细胞源性神经营养因子等,这些多效功能因子能够激发神经再生/保护效应,提高先天性巨结肠的临床转化潜能。Cell transplantation is a potential strategy for radical treatment of Hirschsprung disease(HSCR).However,it has currently encountered many bottlenecks.Clinicians should"trace back to the root"to improve the level of re-understanding.In addition to an absence of ganglion cells and a presence of hypertrophic nerve fibers,HSCR also has a variety of intestinal microenvironment abnormalities.Various intestinal microenvironment abnormalities existing in HSCR were summarized to explore Schwann precursor cells and multi-factor metabolites of intestinal microenvironment,such as short-chain fatty acids and glial-derived neurotrophic factors with neurogenetic potential,exerting neurogenesis/neuroprotection and improving the clinical transformation potential of HSCR.

关 键 词：先天性巨结肠 神经再生 肠神经嵴前体细胞 肠道微环境 

分 类 号：R726.5[医药卫生—儿科]