HIV阳性患者T淋巴细胞水平与胃肠疾病关系的研究  

A study on the relationship between T lymphocyte level and gastrointestinal diseases in HIV positive patients

作　　者：茹克亚·买买提 刘雪芳 Rukeya·Maimaiti;LIU Xue-fang(Department of Gastroenterology,the Eighth Affiliated Hospital of Xinjiang Medical University,830000 Urumqi,Xinjiang,China)

机构地区：[1]新疆医科大学第八附属医院消化科,新疆乌鲁木齐830000

出　　处：《临床消化病杂志》2023年第4期293-297,共5页Chinese Journal of Clinical Gastroenterology

基　　金：“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(No:2018 ZX10302104)。

摘　　要：[目的]分析T淋巴细胞水平(CD_(4+)、CD_(8+))与人类免疫缺陷病毒(HIV)阳性患者并发胃肠疾病的关系。[方法]回顾性分析接受治疗并完成随访的86例HIV阳性患者(对照组)资料,并收集同期于医院接受治疗并完成随访的86例HIV阳性且治疗后并发胃肠疾病患者(观察组)的资料。完整资料包括一般资料、实验室指标检测结果资料,由研究人员统计患者资料,重点记录T淋巴细胞实验室指标,分析患者初诊当天早晨外周血CD_(4+)、CD_(8+)与患者并发胃肠疾病的关系。[结果]观察组与对照组年龄、性别、HIV感染病程、合并高血压、合并糖尿病、合并血脂异常、HIV感染途径对比,差异无统计学意义(P>0.05);观察组IL-6、NETs、CD_(8+)水平均高于对照组,CD_(4+)水平低于对照组,差异有统计学意义(P<0.05);回归分析结果显示,HIV阳性患者初诊当天早晨外周血IL-6、NETs、CD_(4+)、CD_(8+)水平与患者并发胃肠疾病有关,外周血IL-6、NETs、CD_(8+)高表达、CD_(4+)低表达可能是HIV阳性患者并发胃肠疾病的风险因子(OR>1,P<0.05);绘制ROC曲线,结果显示,HIV阳性患者初诊当天早晨外周血IL-6、NETs、CD_(4+)、CD_(8+)水平分别预测胃肠疾病发生风险的AUC均>0.80,有一定预测价值。[结论]T淋巴细胞水平与HIV阳性患者并发胃肠疾病有关,可能是患者并发胃肠疾病的风险因子对预测患者并发胃肠疾病风险有一定价值。[Objective]To analyze the relationship between T lymphocyte level(CD_(4+),CD_(8+))and gastrointestinal diseases in patients with human immunodeficiency virus(HIV)infection.[Methods]Total 172 HIV positive patients who received treatment and completed follow-up in our hospital from January 2019 to January 2020 were retrospectively analyzed.The 86 patients with gastrointestinal diseases after treatment were collected,set as the observation group.The other 86 cases without gastrointestinal diseases at the same period were set as the control group.The collected data included general characters,results of laboratory index test,especially the T lymphocyte.The relationship between CD_(4+),CD_(8+)in peripheral blood and gastrointestinal diseases on the morning of the first visit(received treatment and diagnosis at the first time in hospital)was analyzed.[Results]The age,gender,duration of HIV infection,complication of hypertension,diabetes mellitus,hyperlipidemia and HIV infection pathway in the two groups had no statistical significant difference(P>0.05).The levels of IL-6,NETs and CD_(8+)in the observation group were higher than those in the control group,while the level of CD_(4+)in the observation group was lower than that in the control group with statistical significant difference(P<0.05).The results of regression analysis showed that the levels of IL-6,NETs,CD_(4+)and CD_(8+)in peripheral blood of HIV positive patients on the morning of initial diagnosis were related to gastrointestinal diseases of patients,in which high expression of IL-6,NETs,CD_(8+)and low expression of CD_(4+)in peripheral blood might be risk factors for gastrointestinal diseases(OR>1,P<0.05).The ROC curve showed that the AUC of IL-6,NETs,CD_(4+)and CD_(8+)levels in peripheral blood of HIV positive patients in the morning of initial diagnosis that respectively predicted the risk of gastrointestinal diseases were all 0.80,which had certain predictive value.[Conclusion]T lymphocyte level is associated with gastrointestinal diseases in HIV positiv

关 键 词：人类免疫缺陷病毒 胃肠疾病 T淋巴细胞 相关性 

分 类 号：R373[医药卫生—病原生物学]