孕妇血清IgG抗A(B)抗体效价积分检测预估母婴ABO血型不合新生儿溶血病价值  

Erum IgG anti-A/B Titer Score of Pregnant Women with Blood type O for Predicting the Hemolytic Disease of Newborn

作　　者：杨晓亚 阳绪华 高裕华 赵义曼 毕利博 YANG Xiaoya;YANG Xuhua;GAO Yuhua(Department of Blood transfusion,Bethune International Peace Hospital of PLA 050082)

机构地区：[1]联勤保障部队第九八〇医院输血医学科,河北石家庄050082

出　　处：《临床输血与检验》2023年第4期484-489,共6页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：河北省卫生健康委医学科学研究课题计划(No.20211033)资助。

摘　　要：目的探讨产前进行孕妇血清IgG抗体效价积分检测对母婴ABO血型不合新生儿溶血病(HDN)发病的预测价值。方法针对45例O型高效价足月孕妇进行研究,利用抗人球蛋白试管法检测孕妇血清的抗A(B)IgG抗体效价,同时给每一管的凝集强度进行计分,将各管计分相加得该待检标本的效价积分,分析孕妇血清IgG抗体效价积分和产后新生儿患HDN的相关性。结果45例高效价孕妇中,有27例产后新生儿被诊断为ABO血型不合HDN。随着孕妇血清抗A(B)IgG抗体效价的增高,新生儿HDN患病率呈上升趋势,但各效价组之间差异无统计学意义(P=0.224)。针对效价积分与HDN相关性的分析发现,患HDN的新生儿,其母血清抗A(B)IgG抗体效价积分显著高于未患HDN的,效价积分与HDN发病之间有显著统计学相关性,相关系数为-0.665,其相关性比抗体效价和HDN发病之间更为密切。结论利用孕妇血清抗A(B)IgG抗体效价积分值能够更准确的预测产后ABO血型不合新生儿溶血病的患病可能性,有一定的临床应用价值。Objective To study the value of serum IgG anti-A/B titer score of pregnant women with blood type O for predicting the hemolytic disease of newborn(HDN).Methods 45 blood type O pregnant women with high IgG antibody titer were selected as the research object.The IgG titer of the mother was measured by anti-human globulin test carried out by traditional tubing test.At the same time,the score of each tube were measured according to the intensity of agglutination.To obtain the antibody titer scores of the tested samples,add up the scores of the tubes.The correlations between the IgG antibody titer score of pregnant women and the possibility of HDN of newborns were analyzed.Results Of the 45 newborns,27 were diagnosed as HDN.With the serum antibody titer of pregnant women increasing,the prevalence of HDN shows an upward trend,but the difference between different antibody titer groups was not statistically significant.There was a statistically significant correlation between the titer score and the incidence of HDN,and the correlation coefficient was-0.665.Conclusion Compared to antibody titer,the titer score of pregnant mothers is more closely related to the incidence rate of HDN of newborn.The IgG antibody titer score of pregnant women has more clinical significance in predicting the HDN of hemolytic disease.

关 键 词：孕妇 血型抗体 新生儿溶血病 IGG抗体效价 效价积分 

分 类 号：R457[医药卫生—治疗学]