单采血浆捐献后部分血浆蛋白及电解质变化趋势和影响因素研究  

Effects of Plasmapheresis Collection on Serum Proteins and Electrolytes after Plasma Donation

作　　者：王小兵 李婉 肖光林 黄敬 马晓军 陈飞 李长清[2] 王娅[2] 罗艳侠[1] WANG Xiaobing;LI Wan;XIAO Guanglin(School of Public Health,Capital Medical University,Beijing 10000)

机构地区：[1]首都医科大学公共卫生学院,北京100069 [2]中国医学科学院北京协和医学院输血研究所,四川成都610052 [3]四川远大蜀阳药业有限责任公司,611730 [4]剑阁蜀阳单采血浆有限公司,628300 [5]苍溪蜀阳单采血浆有限公司,628402

出　　处：《临床输血与检验》2023年第4期503-509,共7页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：中国医学科学院医学与健康科技创新工程重大协同创新项目-血液安全保障及新产品新技术研究(No.2021-I2M-1-060)资助

摘　　要：目的了解单采血浆对献浆者部分血浆蛋白和电解质水平的影响,为保障献浆者健康安全提供有力的科学依据。方法2022年2月—5月在四川省两家单采血浆站招募223名新献浆者,经纳排后共纳入118名献血浆者。收集献浆者人口统计学信息,并持续随访观察一年,检测每次捐献血浆前部分血浆蛋白及电解质水平。分析部分血浆蛋白及电解质水平的变化趋势,利用协方差分析排除献浆前各相关指标基线水平的干扰,分析献浆次数对献浆后相关指标变化的影响,并采用多重线性回归探索相关指标的影响因素。结果男性献浆者铁蛋白(SF,serum ferritin)水平随献浆次数增加呈现一定下降趋势,其余成分水平则随献浆次数增加无明显波动。协方差分析控制混杂因素后,献浆次数对SF的影响无统计学意义。多重线性回归结果显示,在控制了基线水平之后,献浆次数对SF水平的影响无统计学意义。结论持续一年低频次捐献单采血浆不会对献浆者血浆蛋白及电解质水平产生统计学上的显著影响。Objective To investigate the effects of plasmapheresis on donor serum proteins and electrolytes to provide scientific basis for the health and safety of plasma donors.Methods A total of 223 new plasma donors were recruited from two plasmapheresis stations in Sichuan Province from February to May 2022,of which 118 donors were enrolled.The demographic information of donors was collected and followed up for one year.The plasma proteins and electrolytes levels were detected before each plasma donation.The change trend of plasma proteins and electrolytes levels was analyzed,and the covariance analysis was used to eliminate the interference of the baseline level of each relevant index before donation.The influence of donation times on the change of relevant indicators after donation was analyzed,and multiple linear regression was used to explore the influencing factors of relevant indicators.Results The levels of serum ferritin(SF)in male donors decreased with the increase of donation times,while the levels of other components did not fluctuate significantly.After controlling for confounding factors by covariance analysis,there was no statistical significance in the influence of donor times on SF.The results of multiple linear regression showed that the effect of donation times on SF level was not statistically significant after controlling the baseline level.Conclusion Low frequency plasma donation over a period of one year did not have statistically significant effects on plasma proteins and electrolyte levels in donors.

关 键 词：单采血浆 铁蛋白 血浆蛋白 电解质 随访研究 

分 类 号：R457.1[医药卫生—治疗学]