运动干预糖尿病肾病的机制及应用研究进展  

Research progress in mechanism and application of exercise intervention in diabetes nephropathy

作　　者：戴刘宴 张梅[1] DAI Liuyan;ZHANG Mei(Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2023年第9期1307-1312,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81974103);2021年度“临床能力提升工程”医疗项目(JSPH-MA-2021-3);江苏省科教能力提升工程江苏省医学重点学科/实验室项目(ZDXK202202)。

摘　　要：运动是糖尿病管理中不可或缺的一个部分,对于糖尿病肾病的防治起着积极作用。运动可以独立于血糖控制,减少糖尿病患者的白蛋白尿,改善糖尿病患者预后。已有研究表明,运动通过改善体内葡萄糖稳态、内皮细胞功能、减轻氧化应激和炎症、调节肾素-血管紧张素-醛固酮系统以及肌动蛋白的生物作用等,改善肾功能。目前指南中推荐的主要运动类型包括有氧运动、阻力运动、组合运动和柔韧性运动,临床上应根据患者个体情况选择合适的运动方式。Exercise is an important component of diabetes management and plays a positive role in the prevention and treatment of diabetic kidney disease.Exercise reduces the albuminuria and improves renal outcomes in patients with diabetes,which is independent of blood glucose control.Previous studies have shown that exercise can improve renal function by improving glucose homeostasis and endothelial cell function,reducing oxidative stress and inflammation,regulating renin⁃angiotensin⁃aldosterone system and biological action of actin.Recommended types of exercise include aerobic exercise,resistance exercise,combination exercise and flexibility exercise.Appropriate exercise methods should be selected according to individual condition in clinical practice.

关 键 词：运动 糖尿病肾病 糖尿病 

分 类 号：R587.2[医药卫生—内分泌]