下丘脑室旁核调控心血管活动的研究进展  

Research progress of hypothalamic paraventricular nucleus regulating cardiovascular activity

作　　者：刘宣宣 许驭[1] 王晨辰 綦振宝 韩莹 LIU Xuanxuan;XU Yu;WANG Chenchen;QI Zhenbao;HAN Ying(Department of Physiology,Nanjing Medical University,Nanjing 211166;Department of Physiology,Kangda College of Nanjing Medical University,Lianyungang 222000;Department of Stomatology,Qinhuai Medical District,Eastern Theater Command General Hospital,Nanjing 210002;Engineering Training Center,Qilu University of Technology,Jinan 250000,China)

机构地区：[1]南京医科大学生理学系,江苏南京211166 [2]南京医科大学康达学院生理学教研室,江苏连云港222000 [3]东部战区总医院秦淮医疗区口腔科,江苏南京210002 [4]齐鲁工业大学(山东省科学院)工程训练中心,山东济南250000

出　　处：《南京医科大学学报（自然科学版）》2023年第9期1313-1318,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(82270455);江苏省高校基础科学(自然科学)研究项目(22KJD180003);南京医科大学康达学院第二期“科研人才培养计划”项目(KD2022KYRC005)。

摘　　要：随着中国步入老龄化社会的进程逐渐加快,各种心血管疾病(包括慢性心力衰竭、心肌梗死和高血压等)的发病率逐年上升,目前还缺乏有效的预防手段。越来越多的研究发现,中枢神经系统与心血管生理机能的调控有密不可分的交互作用,其中下丘脑室旁核(paraventricular nucleus,PVN)中神经元和多种细胞因子参与调控心血管活动,是心血管活动的关键性调节中枢。本文旨在归纳和总结近年来PVN在调控心血管活动中作用及机制的研究进展。With the gradual acceleration of China’s aging society,the incidence rate of various cardiovascular diseases is increasing,including chronic heart failure,myocardial infarction,and hypertension,etc.There is still a lack of effective prevention measures.More and more studies have found that the central nervous system has an inseparable interaction with the regulation of cardiovascular physiological functions.Among them,neurons and various cytokines in the paraventricular nucleus(PVN)of the hypothalamus participate in the regulation of cardiovascular activities,which is a key regulatory center for regulating cardiovascular activities.This article aims to summarize and conclude the recent research progress on the role and mechanism of PVN in regulating cardiovascular activity.

关 键 词：下丘脑室旁核 交感神经 心交感传入反射 心血管活动 

分 类 号：R331.3[医药卫生—人体生理学]