血清IAP、孕酮、雌二醇及PAPP-A水平对妊娠早期胚胎停止发育的预测价值  

Predictive Value of Serum IAP,Progesterone,Estradiol,and PAPP-A Levels in Early Pregnant Embryo Arrest

作　　者：曾帮智 杨海蓉 ZENG Bang-zhi;YANG Hai-rong(Department of Laboratory Medicine,Ankang Maternal and Child Health Hospital,Ankang Shaanxi 725000)

机构地区：[1]安康市妇幼保健院检验科,陕西安康725000 [2]陕西省延安市宝塔区人民医院妇产科,陕西延安716000

出　　处：《医学临床研究》2023年第8期1161-1163,1167,共4页Journal of Clinical Research

基　　金：安康市科学技术局课题(AK2020-SF-12)。

摘　　要：【目的】探讨血清免疫抑制酸性蛋白(IAP)、孕酮(P)、雌二醇(E_(2))及妊娠相关蛋白-A(PAPP-A)水平预测妊娠早期胚胎停止发育的价值。【方法】安康市妇幼保健院收治的70例妊娠早期胚胎停止发育的孕妇纳入观察组,另选取同期于本院接受孕检的50例正常早期妊娠孕妇为对照组。分别于孕8周、10周、12周检测所有孕妇血清P、E_(2)、PAPP-A及IAP水平,比较两组孕妇在孕8周、10周、12周时血清P、E_(2)、PAPP-A、IAP水平。【结果】观察组孕8周时IAP水平显著高于对照组(P<0.05),P、E_(2)、PAPP-A水平显著低于对照组(P<0.05)。观察组孕10周时IAP水平显著高于对照组(P<0.05),P、E_(2)、PAPP-A水平显著低于对照组(P<0.05)。观察组孕12周时IAP水平显著高于对照组(P<0.05),P、E_(2)、PAPP-A水平显著低于对照组(P<0.05)。【结论】妊娠早期胚胎停止发育的孕妇血清P、E_(2)、PAPP-A水平均显著低于正常孕妇,IAP水平明显高于正常孕妇,上述指标对妊娠过程产生重要影响,可作为妊娠早期胚胎停止发育的预测指标。【Objective】This study aims to explore the predictive value of serum immune-suppressive acid protein(IAP),progesterone(P),estradiol(E_(2)),and pregnancy-associated plasma protein-A(PAPP-A)levels in predicting embryo arrest in early pregnancy.【Methods】Seventy pregnant women with early pregnant embryo arrest admitted to Ankang Maternal and Child Health Hospital were included in the observation group,while 50 normal early pregnant women who underwent prenatal examination in the same period at the hospital were selected as the control group.Serum levels of P,E_(2),PAPP-A,and IAP were measured at gestational weeks 8,10,and 12 in both groups,and the differences in serum levels of P,E_(2),PAPP-A,and IAP between the two groups at gestational weeks 8,10,and 12 were compared.【Results】At gestational week 8,the IAP level in the observation group was significantly higher than that in the control group(P<0.05),while the levels of P,E_(2)and PAPP-A were significantly lower than those in the control group(P<0.05).At gestational week 10,the IAP level in the observation group was significantly higher than that in the control group(P<0.05),while the levels of P,E_(2),and PAPP-A were significantly lower than those in the control group(P<0.05).At gestational week 12,the IAP level in the observation group was significantly higher than that in the control group(P<0.05),while the levels of P,E_(2),and PAPP-A were significantly lower than those in the control group(P<0.05).【Conclusion】The serum levels of P,E_(2),and PAPP-A in pregnant women with early pregnancy embryo arrest were significantly lower than those in normal pregnant women,while the IAP level was significantly higher.These indicators have important implications for the pregnancy process and can serve as predictive markers for embryo arrest in early pregnancy.

关 键 词：妊娠初期 胚胎发育/生理学 孕酮/血液 雌二醇/血液 

分 类 号：R714.431[医药卫生—妇产科学]