单次负荷小剂量艾司洛尔对老年无痛胃镜检查时血流动力学参数的影响  

Effect of Single Load with Low Dose Esmolol on Hemodynamic Parameters in Elderly Patients Undergoing Painless Gastroscopy

作　　者：李虎 李海英[2] LI Hu;LI Hai-ying(Department of Anesthesiology,Shaanxi Provincial Communications Hospital,Xi'an Shaanxi 710068)

机构地区：[1]陕西省交通医院手术麻醉科,陕西西安710068 [2]延安市人民医院麻醉科,陕西延安716000

出　　处：《医学临床研究》2023年第8期1190-1192,1196,共4页Journal of Clinical Research

摘　　要：【目的】观察单次负荷小剂量艾司洛尔对老年无痛胃镜检查时血流动力学参数的影响。【方法】行无痛胃镜检查的160例老年患者,随机分为观察组和对照组,每组80例。观察组患者静脉注射小剂量艾司洛尔0.3 mg/kg,对照组静脉注射大剂量艾司洛尔0.5 mg/kg,两组注射时间控制在15~30 s。比较两组检查前后血流动力学参数[心率(HR)、收缩压(SBP)、舒张压(DBP)以及血氧饱和度(SpO_(2))]、检查后两组留院观察时间、麻醉清醒时间以及简易精神状态评价量表(MMSE)评分、麻醉用量以及不良反应发生情况。【结果】检查后,两组HR、SBP、DBP均低于检查前(P<0.05),但观察组HR、SBP、DBP高于对照组(P<0.05),两组检查前后SpO_(2)比较,差异无统计学意义(P>0.05);两组留院观察时间、麻醉清醒时间以及MMSE评分和麻醉药用量比较,差异无统计学意义(P>0.05);观察组不良反应发生率显著低于对照组(P<0.05)。【结论】艾司洛尔用于老年无痛胃镜检查时的麻醉效果显著,其中小剂量艾司洛尔更有利于稳定血液循环,且不良反应小,推荐临床应用。【Objective】To investigate the effect of single load with small dose esmolol on hemodynamic parameters of the elderly patients undergoing painless gastroscopy.【Methods】A total of 160 elderly patients underwent painless gastroscopy were randomly divided into the observation group and the control group,with 80 cases in each group.The observation group was given a low dose of esmolol 0.3 mg/kg intravenously,while the control group was given a high dose of esmolol 0.5 mg/kg intravenously.The injection time of the two groups was administrated within 15 to 30 seconds.Hemodynamic parameters[heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP)and oxygen saturation(SpO_(2))]before and after examination were compared between the two groups.After examination,the length of hospital observation,the duration of anesthesia wakefulness,the score of the Simple Mental State Assessment Scale(MMSE),the amount of anesthesia and the occurrence of adverse reactions between the two groups were compared as well.【Results】After examination,HR,SBP and DBP levels of the two groups were lower than those before examination(P<0.05),however,HR,SBP and DBP of the observation group were higher than those of the control group(P<0.05).There was no statistical significance in SpO_(2)between the two groups before and after examination(P>0.05).There were no significant differences in hospital observation time,anesthetic waking time,MMSE score and anesthetic dosage between the two groups(P>0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).【Conclusion】Esmolol has a significant anesthetic effect in the elderly for painless gastroscopy,and small doses of esmolol are more conducive to stable blood circulation,and the adverse reactions are small,so it is recommended for clinical application.

关 键 词：胃镜检查 丙醇胺类/治疗应用 血流动力学 

分 类 号：R459.3[医药卫生—治疗学]