α1-AT/DNaseⅠ、HBD-1、SF在重症儿童社区获得性肺炎患儿中的表达及其临床意义  

The Expression and Clinical Significance ofα1-AT/DNaseⅠ,HBD-1,and SF in Children with Severe Community Acquired Pneumonia

作　　者：周宇阳 杨军杰[2] ZHOU Yu-yang;YANG Jun-jie(Kaifeng Children's Hospital,Kaifeng Henan 475000)

机构地区：[1]开封市儿童医院,河南开封475000 [2]河南大学淮河医院,河南开封475000

出　　处：《医学临床研究》2023年第8期1211-1213,1217,共4页Journal of Clinical Research

摘　　要：【目的】探讨α1-抗胰蛋白酶(α1-AT)/DNA酶Ⅰ(DNaseⅠ)、β-防御素1(HBD-1)、铁蛋白(SF)在重症社区获得性肺炎(SCAP)患儿中的表达及其临床意义。【方法】选取2020年1月至2021年5月开封市儿童医院收治的98例SCAP患儿(观察组),根据肺炎严重指数(PSI)分为低危组(n=15)、中危组(n=52)、高危组(n=31),根据检测结果分为细菌性肺炎组(n=50)、支原体肺炎组(n=22)、病毒性肺炎组(n=26),同时选取同期于本院体检的62例健康儿童作为对照组。比较不同组间血清α1-AT/DNaseⅠ、HBD-1、SF水平,采用Spearman法分析α1-AT/DNaseⅠ、HBD-1、SF与疾病严重程度的相关性,采用受试者工作特征(ROC)曲线评估上述指标对SCAP的诊断价值。【结果】观察组血清α1-AT/DNaseⅠ、HBD-1、SF水平高于对照组,差异有统计学意义(P<0.05)。单因素方差分析显示,不同疾病严重程度的SCAP患儿血清α1-AT/DNaseⅠ、HBD-1、SF水平比较,差异有统计学意义(P<0.05)。中危组、高危组血清α1-AT/DNaseⅠ、HBD-1、SF水平高于低危组,且高危组高于中危组,差异有统计学意义(P<0.05)。支原体肺炎组、病毒性肺炎组α1-AT/DNaseⅠ、HBD-1、SF水平高于细菌性肺炎组(P<0.05),支原体肺炎组、病毒性肺炎组比较,差异无统计学意义(P>0.05)。Spearman相关性分析显示,α1-AT/DNaseⅠ、HBD-1、SF均与疾病严重程度呈正相关(r_(s)=0.632、0.524、0.531,均P<0.01)。ROC曲线分析显示,α1-AT/DNaseⅠ、HBD-1、SF联合检测的曲线下面积、敏感度、特异度明显高于单项检测(P<0.05)。【结论】SCAP患儿血清中α1-AT/DNaseⅠ、HBD-1、SF水平异常升高,且与病情程度有关,联合检测可提高SCAP诊断价值。【Objective】To investigate the expression and clinical significance ofα1-antitrypsin(α1-AT)/DNaseⅠ(DNaseⅠ),β-Defensins 1(HBD-1),and ferritin(SF)in children with severe community acquired pneumonia(SCAP).【Methods】A total of 98 children with SCAP admitted to Kaifeng Children's Hospital from January 2020 to May 2021 were selected as the observation group.They were divided into low risk group(n=15),medium risk group(n=52),and high risk group(n=31)based on the pneumonia severity index(PSI).According to the test results,they were divided into bacterial pneumonia group(n=50),mycoplasma pneumonia group(n=22),and viral pneumonia group(n=26).At the same time,62 healthy children who underwent physical examination in our hospital were selected as the control group.The serum levels ofα1-AT/DNaseⅠ,HBD-1,and SF were compared between different groups.The Spearman method was used to analyze the correlation betweenα1-AT/DNaseⅠ,HBD-1,and SF and disease severity.The diagnostic value of the above for SCAP was evaluated using the receiver operating characteristic(ROC)curve.【Results】The serum levels ofα1-AT/DNaseⅠ,HBD-1,and SF in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Univariate analysis of variance showed that there was a statistically significant difference in serumα1-AT/DNaseⅠ,HBD-1,and SF levels among SCAP patients with different disease severity levels(P<0.05).The serum levels ofα1-AT/DNaseⅠ,HBD-1,and SF in the medium and high-risk groups were higher than those in the low risk group,and the high-risk group was higher than the medium risk group,with statistical significance(P<0.05).The levels ofα1-AT/DNaseⅠ,HBD-1,and SF in the mycoplasma pneumonia group and viral pneumonia group were higher than those in the bacterial pneumonia group(P<0.05).There was no statistically significant difference between the mycoplasma pneumonia group and viral pneumonia group(P>0.05).Spearman correlation analysis showed thatα1-AT/DNas

关 键 词：肺炎 社区获得性感染 Α1抗胰蛋白酶 脱氧核糖核酸酶Ⅰ Β防御素 铁蛋白质类 

分 类 号：R563.1[医药卫生—呼吸系统]