牛科物种甲状腺激素应答(THRSP)基因在乳脂合成中的功能作用研究进展  

Research Progress on the Functional Role of Thyroid Hormone Response(THRSP)Gene in Milk Fat Synthesis in Bovine Species

作　　者：吴宇 苗永旺[1] WU Yu;MIAO Yong-wang(College of Animal Science and Technology,Yunnan Agricultural University,Kunming,Yunnan 650210 China)

机构地区：[1]云南农业大学动物科学技术学院,昆明650210

出　　处：《中国牛业科学》2023年第3期70-75,81,共7页China Cattle Science

基　　金：国家自然科学基金项目(32260822,31460582)。

摘　　要：甲状腺激素应答(Thyriod hormone responsive,THRSP)基因参与动物从头脂肪酸的合成,主要在肝脏、乳腺和脂肪组织中表达,在转录水平上受到与脂代谢相关因子的诱导并作为转录激活剂调节下游脂肪合成酶基因的表达。本文对牛科物种THRSP基因的结构和功能、转录调控机制和调节脂肪酸合成的生物学路径及该基因多态性对泌乳性状的影响等方面的研究进展进行了综述。Thyriod hormone responsive(THRSP)gene is involved in animal de novo fatty acid synthesis,mainly expressed in liver,mammary gland and adipose tissues,induced by factors related to lipid metabolism at the transcriptional level,and acts as transcriptional activators to regulate the expression of downstream lipid synthase genes.This paper reviews the research progress on the structure and function of THRSP gene,the mechanism of transcriptional regulation,the biological pathway for regulating fatty acid synthesis,and the effects of polymorphisms of the gene on lactation traits in bovine species.

关 键 词：THRSP基因 乳脂合成 调控机制 信号通路 基因多态性 

分 类 号：S823[农业科学—畜牧学]