基于中医传承计算平台探究牡蛎和煅牡蛎临床用药规律  

Clinical medication rules of oyster and calcined oyster based on traditional Chinese medicine inheritance computing system

作　　者：许金塔 刘翔翔 徐婕 王英豪[1] 王颖峥 何丽君[2] XU Jinta;LIU Xiangxiang;XU Jie;WANG Yinghao;WANG Yingzheng;HE Lijun(College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Pharmacy Department,The Affiliated People's Hospital,Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]福建中医药大学附属人民医院药剂科,福建福州350004

出　　处：《中国海洋药物》2023年第4期63-70,共8页Chinese Journal of Marine Drugs

基　　金：国家中医药管理局临床中药学高水平中医药重点学科建设项目(国中医药人教函[2023]85号);福建省本科高校教育教学改革研究重大项目(FBJG20200024)资助。

摘　　要：目的通过分析临床使用牡蛎和煅牡蛎的中药处方治疗疾病的用药情况,为牡蛎和煅牡蛎用药规律的深入挖掘提供参考。方法收集2019年医院门诊使用牡蛎及煅牡蛎治疗疾病的处方,共计4352张。通过中医传承计算平台V3.0软件,运用软件的频次统计、关联规则、聚类分析等功能,分析牡蛎的治疗疾病、用药配伍、性味归经等规律。结果在4352张处方中,证型治疗方面,牡蛎以肝气郁结、肝郁脾虚证为主;煅牡蛎则以治疗脾胃气虚证为多。疾病治疗方面,牡蛎多用于不寐;煅牡蛎集中在胃脘痛。常用药物配伍方面,牡蛎与龙骨、柴胡等药配伍应用为多;煅牡蛎与柴胡、茯苓、煅龙骨等药配伍应用为多。牡蛎和煅牡蛎最常用的剂量均为30 g。性味归经方面,牡蛎和煅牡蛎配伍用药多为性温、寒或平,味甘、苦或辛。但牡蛎配伍用药偏性寒(39.21%),归肝经(16.75%)、脾经(16.23%)、肺经(16.12%),煅牡蛎配伍用药偏性温(38.19%),归脾经(22.13%)、肺经(19.64%)。结论利用该平台得出牡蛎和煅牡蛎的核心药物配伍和配伍用药规律,可为牡蛎及煅牡蛎的临床合理应用提供参考。Objective To provide a reference for the deeper excavation of oyster and calcined oyster medication patterns by analyzing the clinical use of oyster and calcined oyster for the treatment of diseases.Methods A total of 4 352 prescriptions using oyster and calcined oyster at the hospital in 2019 were collected.Based on the traditional Chinese medicine inheritance computing system(TCMiCS) V3.0,the frequency statistics,association rules,cluster analysis and other functions of the software were applied to the laws of oyster and calcined oyster in the treatment of diseases,compatibility of medicines,the properties,flavors and channel tropism.Results Among the 4 352 prescriptions,in terms of syndrome patterns,oyster was mainly used for liver qi stagnation,liver stagnation and spleen deficiency syndrome;calcined oyster was mostly used to treat spleen-stomach qi deficiency syndrome.In terms of disease treatment,oyster was mostly used for insomnia;calcined oyster was concentrated in epigastric pain.In terms of compatibility of common medicines,oyster frequently used with longgu,Bupleurum Chinense.Calcined oyster frequently used with Bupleurum,poria cocos,calcined longgu.The most commonly used doses of oyster and calcined oyster were both 30 g.In terms of the properties,flavors and channel tropism,the compatibilities of the medicines for oyster and calcined oyster was mostly warm,cold or flat;sweet,bitter or pungent,respectively.However,the properties of compatible medicine for oyster were cold(39.21%),liver meridian(16.75%),spleen meridian(16.23%) and lung meridian(16.12%).And the properties of compatible medicine for calcined oyster were warm(38.19%),spleen meridian(22.13%) and lung meridian(19.64%).Conclusion The core compatibility and medication rules of oyster and calcined oyster obtained by TCMiCS could provide a reference for the rational clinical application of oyster and calcined oyster.

关 键 词：牡蛎 煅牡蛎 用药分析 临床应用 中医传承计算平台V3.0 

分 类 号：R282.77[医药卫生—中药学]