丹红注射液对急性缺血性脑卒中患者颈动脉斑块及血清C反应蛋白的影响  

Effect of danhong injection on carotid plaque and serum C-reactive protein in patients with acute ischemic stroke

作　　者：张卓成[1] 计高荣[1] 汤雪峰[2] 何淼[1] Zhang Zhuocheng;Ji Gaorong;Tang Xuefeng;He Miao(Department of Emergency,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China;Department of General Surgery,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

机构地区：[1]上海中医药大学附属曙光医院急诊科,上海200021 [2]上海中医药大学附属曙光医院普外科,上海200021

出　　处：《血管与腔内血管外科杂志》2023年第8期940-943,共4页Journal of Vascular and Endovascular Surgery

基　　金：上海市2021年度“科技创新行动计划”医学创新研究专项项目(21Y11920800)。

摘　　要：目的探讨丹红注射液对急性缺血性脑卒中患者颈动脉斑块及血清C反应蛋白的影响。方法收集2019年8月至2022年6月于上海中医药大学附属曙光医院就诊的120例急性缺血性脑卒中患者,按照住院期间是否使用丹红注射液将其分为丹红组(n=56)和对照组(n=64)。收集两组患者入院时的一般信息、病史信息、血液检测指标、影像学检查等。比较两组患者治疗前后的血清C反应蛋白水平、颈动脉斑块面积、颈动脉斑块厚度、颈动脉内膜中层厚度,记录两组患者住院期间的并发症发生情况。结果治疗后,丹红组患者颈动脉斑块面积、颈动脉斑块厚度、颈动脉内膜中层厚度均小于对照组患者,C反应蛋白水平低于对照组患者,差异均有统计学意义(P<0.05)。住院期间丹红组患者并发生总发生率为8.9%(5/56),与对照组患者的12.5%(8/64)比较,差异无统计学意义(P>0.05)。结论丹红注射液可以降低血清中的C反应蛋白水平,缩小颈动脉斑块,安全有效,值得在临床上推广应用。Objective To investigate the effect of danhong injection on carotid plaque and serum C-reactive protein in patients with acute ischemic stroke.Method A total of 120 patients with acute ischemic stroke who were treated in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from August 2019 to June 2022 were collected.They were divided into danhong group(n=56)and control group(n=64)according to the employment of danhong injections during hospitalization.The general data,medical history information,blood test indicators,and imaging examinations of the two groups of patients were collected.Serum C-reactive protein levels,carotid plaque area,carotid plaque thickness,and carotid intima-media thickness were compared between the two groups before and after the treatment.The occurrence of complications during the hospitalization of the two groups of patients was also recorded.Result After the treatment,the carotid plaque area,carotid plaque thickness,and carotid intima-media thickness in the danhong group were smaller than those in the control group,the C-reactive protein level was lower than that in the control group,the differences were statistically significant(P<0.05).During hospitalization,the total incidence of complications in the danhong group was 8.9%(5/56),and the difference was not statistically significant compared with 12.5%(8/64)in the control group(P>0.05).Conclusion Danhong injection could reduce the level of C-reactive protein in serum and shrink carotid artery plaque,the medication is safe,effective and worthy of clinical application.

关 键 词：急性缺血脑卒中 颈动脉斑块 C反应蛋白 丹红注射液 

分 类 号：R543[医药卫生—心血管疾病]