茄尼醇及其衍生物在纳米载药系统中的应用研究  

Application of Solanesol and its Derivatives in Nano Delivery System

作　　者：齐培兰 QI Peian(Henan Vocational University of Science and Technology,Zhoukou 466000,China)

机构地区：[1]河南科技职业大学,河南周口466000

出　　处：《生物化工》2023年第4期203-205,共3页Biological Chemical Engineering

摘　　要：大多数用于药物输送的传统纳米载药系统是由缺乏治疗活性的惰性载体材料制成,大量的药物载体物质可能会在体内引起外源性生物毒性和相关的代谢问题,而使用多功能智能给药系统可以减少对药物载体的需求与其潜在毒性之间的冲突。为此,已开发出一系列具有生物活性的“治疗载体”。茄尼醇因其丰富的药理活性和生物相容性而备受关注,本文详细介绍了茄尼醇及其衍生物的生理活性,并围绕茄尼醇及其衍生物化学结构优势、在纳米载药体系中的应用研究展开分析论述。Most conventional nanodelivery systems for drug delivery are made of inert carrier materials that lack therapeutic activity.A large number of drug carrier substances may cause exogenous biological toxicity and associated metabolic problems in vivo.The use of multifunctional intelligent drug delivery systems can reduce the conflict between the need for drug carriers and their potential toxicity.A range of bioactive “therapeutic vectors” have been developed.Solanesol has attracted much attention due to its rich pharmacological activity and biocompatibility.This paper introduced the physiological activity of solanesol and its derivatives in detail,and analyzed and discussed the advantages of chemical structure of solanesol and its derivatives and its application in nano drug delivery system.

关 键 词：活性载体 茄尼醇衍生物 载药系统 纳米技术 

分 类 号：TQ463[化学工程—制药化工]