复发性流产患者再次妊娠时血清IL-35和IL-17水平及与妊娠结局的关系  

Levels of serum IL-35 and IL-17 in subsequent pregnancy of patients with recurrent spontaneous abortion and the relationships with pregnancy outcome

作　　者：胡学亭 李玉娟[1] 魏红[1] 庄文玉 于北凯 HU Xue-ting;LI Yu-juan;WEI Hong;ZHUANG Wen-yu;YU Bei-kai(Department of Clinical Laboratory,Weifang Traditional Chinese Medical Hospital,Weifang,Shandong 261041,China)

机构地区：[1]潍坊市中医院检验科,山东潍坊261041

出　　处：《中国妇幼保健》2023年第17期3262-3265,共4页Maternal and Child Health Care of China

基　　金：山东省潍坊市卫生计生委科研项目(2017wsjs109)。

摘　　要：目的检测复发性流产患者再次妊娠时血清白细胞介素-35(IL-35)和白细胞介素-17(IL-17)水平,分析其与妊娠结局的关系。方法选择2019年10月—2020年10月就诊于潍坊市中医院妇产科门诊的50例复发性流产患者,其中复发性流产妊娠成功者18例(复发性流产妊娠成功组),再次流产者32例(复发性流产妊娠再次流产组),选取同一时期的60例健康孕妇为对照组。3组研究对象均随访至妊娠12周,采用酶联免疫吸附试验比较各组血清IL-35、IL-17水平。结果复发性流产妊娠再次流产组血清IL-35和IL-17水平分别为(135.28±42.16)pg/ml和(39.02±9.25)pg/ml;复发性流产妊娠成功组血清IL-35和IL-17水平分别为(278.12±64.02)pg/ml和(19.48±6.04)pg/ml;对照组血清IL-35和IL-17水平分别为(281.46±64.12)pg/ml和(21.92±6.48)pg/ml。与对照组相比,复发性流产妊娠再次流产组血清IL-35水平明显下降,差异有统计学意义(t=9.59,P<0.05),血清IL-17水平明显升高,差异有统计学意义(t=8.42,P<0.05)。与复发性流产妊娠成功组相比,复发性流产妊娠再次流产组血清IL-35水平明显下降,差异有统计学意义(t=8.89,P<0.05),血清IL-17水平明显升高,差异有统计学意义(t=7.71,P<0.05)。对照组和复发性流产妊娠成功组血清IL-35、IL-17水平比较差异均无统计学意义(均P>0.05)。结论IL-35低表达、IL-17高表达与复发性流产的发生有关,检测复发性流产患者再次妊娠时血清IL-35、IL-17水平有助于预测其妊娠结局。Objective To detect the levels of interleukin-35(IL-35)and interleukin-17(IL-17)in peripheral blood of patients with recurrent spontaneous abortion,analyze the relationships with pregnancy outcome.Methods Fifty patienfs with recurrent spontaneous abortion treated in Outpatient of Gynaecology and Obstetrics,Weifang Traditional Chinese Medical Hospital from October 2019 to October 2020 were selected,including 18 patients of successful pregnancy(successful pregnancy group)and 22 patients of re-abortion(re-abortion group),60 healthy pregnant women during the same period were selected as control group.All the study objects were followed up till the 12th week of gestation,enzyme-linked immunosorbent assay was used to compare the expression levels of IL-35 and IL-17.Results The levels of serum IL-35 and IL-17 in re-abortion group were(135.28±42.16)pg/ml and(39.02±9.25)pg/ml,respectively;the levels of serum IL-35 and IL-17 in successful pregnancy group were(278.12±64.02)pg/ml and(19.48±6.04)pg/ml,respectively;the levels of serum IL-35 and IL-17 in control group were(281.46±64.12)pg/ml and(21.92±6.48)pg/ml,respectively.Compared with control group,the level of serum IL-35 in re-abortion group decreased significantly,there was statistically significant difference(t=9.59,P<0.05),the level of serum IL-17 increased significantly,there was statistically significant difference(t=8.42,P<0.05).Compared with successful pregnancy group,the level of serum IL-35 in re-abortion group decreased significantly,there was statistically significant difference(t=8.89,P<0.05),the level of serum IL-17 increased significantly,there was statistically significant difference(t=7.71,P<0.05).There was no statistically significant difference in the levels of serum IL-35 and IL-17 between control group and successful pregnancy group(P>0.05).Conclusion The low level of IL-35 and high level of IL-17 are related to recurrent spontaneous abortion,the detection of serum IL-35 and IL-17 levels might be useful in predicting the pregnancy outcomes in sub

关 键 词：复发性流产 白细胞介素-35 白细胞介素-17 

分 类 号：R714.21[医药卫生—妇产科学]