柴芍乳增胶囊抗炎镇痛作用研究  

Study on Anti-inflammatory and Analgesia Effects of Chaishao Ruzeng Capsule

作　　者：杨铭[1] 肖丹丹 于德伟[1] 赫慧[1] 杨明[1] YANG Ming;XIAO Dandan;YU Dewei;HE Hui;YANG Ming(Jilin Academy of Traditional Chinese Medicine,Changchun 130012,China;School of Pharmacy,Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]吉林省中医药科学院,长春130012 [2]长春中医药大学药学院,长春130117

出　　处：《中国民族民间医药》2023年第17期28-31,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：吉林省科技发展计划,重点研发计划(20200404072YY)。

摘　　要：目的:观察柴芍乳增胶囊抗炎、镇痛作用。方法:灌胃给予大鼠或小鼠柴芍乳增胶囊高、中、低剂量(1.2 g/kg、0.6 g/kg、0.3 g/kg),采用大鼠肉芽肿实验、小鼠热板实验和醋酸扭体实验,观察其抗炎、镇痛作用及对肉芽肿实验大鼠血清中前列腺素E_(2)(PGE_(2))、肿瘤坏死因子(TNF-α)、一氧化氮(NO)、超氧化物歧化酶(SOD)含量的影响。结果:与模型对照组比较,高、中、低剂量组肉芽肿重量明显降低(P<0.05或P<0.01),高、中剂量组PGE_(2)、TNF-α含量降低(P<0.05或P<0.01),高、中、低剂量组NO含量降低、SOD活性增加(P<0.05或P<0.01);与溶剂对照组比较,高、中、低剂量组小鼠热板痛阈值明显提高(P<0.05或P<0.01),高、中、低剂量组小鼠扭体次数减少,高剂量组扭体出现时间延长(P<0.05或P<0.01)。结论:柴芍乳增胶囊具有明显的抗炎镇痛作用,其作用与降低血清中PGE_(2)、TNF-α、NO含量,提高SOD活性有关。Objective To observe the anti-inflammatory and analgesia effects of Chaishao Ruzeng capsule.Methods Rats or mice were given high,medium and low doses(1.2 g/kg,0.6 g/kg,0.3 g/kg)of Chaishao Ruzeng Capsule by intragastric administration.To observe its anti-inflammatory and analgesia effects and effects on the contents of PGE_(2),TNF-α,NO and SOD in serum of granuloma experimental rats.Results Compared with model control group,the granuloma weight in high,medium and low dose groups was significantly decreased(P<0.05 or P<0.01),the contents of PGE_(2) and TNF-αin high and medium dose groups were decreased(P<0.05 or P<0.01),the content of NO in high,medium and low dose groups was decreased and the activity of SOD was increased(P<0.05 or P<0.01).Compared with the solvent control group,the hot plate pain threshold of mice in high-dose,medium-dose and low-dose groups was significantly increased(P<0.05 or P<0.01),the writhing times of mice in high-dose,medium-dose and low-dose groups were decreased,and the writhing time of mice in high-dose group was prolonged(P<0.05 or P<0.01).Conclusions Chaishao Ruzeng capsule has obvious anti-inflammatory and analgesia effects,which are related to decreasing the contents of PGE_(2),TNF-αand NO in serum and increasing the activity of SOD.

关 键 词：柴芍乳增胶囊 抗炎 镇痛 肉芽肿 

分 类 号：R285.5[医药卫生—中药学]