枸橼酸咖啡因联合双水平正压通气治疗新生儿呼吸窘迫综合征的效果  

Effect of caffeine citrate combined with bi-level positive airway pressure ventilation in the treatment of newborn respiratory distress syndrome

作　　者：张贝 高珂 ZHANG Bei;GAO Ke(Neonatology Department,Weinan Maternal and Child Health Hospital,Weinan 714000,China)

机构地区：[1]渭南市妇幼保健院新生儿科,陕西渭南714000

出　　处：《临床医学研究与实践》2023年第26期65-68,共4页Clinical Research and Practice

摘　　要：目的探究枸橼酸咖啡因联合双水平正压通气(BiPAP)治疗新生儿呼吸窘迫综合征(NRDS)的效果。方法选择2019年8月至2020年6月在本院被确诊且接受治疗的74例NRDS患儿为研究对象,以随机数字表法将其分为对照组和观察组,各37例。对照组给予BiPAP治疗,观察组给予枸橼酸咖啡因联合BiPAP治疗。比较两组的治疗效果。结果治疗后,观察组的气道阻力(RAW)、气道峰压(PIP)低于对照组,肺静态顺应性(Cst)大于对照组(P<0.05)。治疗后,观察组的丙二醛(MDA)、内皮素-1(ET-1)水平低于对照组,超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)及一氧化氮(NO)水平高于对照组(P<0.05)。观察组的辅助通气时间、供氧时间及住院时间均短于对照组,治疗期间呼吸暂停次数少于对照组(P<0.05)。结论枸橼酸咖啡因联合BiPAP治疗NRDS的效果较好。Objective To explore the effect of caffeine citrate combined with bi-level positive airway pressure ventilation(BiPAP)in the treatment of newborn respiratory distress syndrome(NRDS).Methods A total of 74 children with NRDS who were diagnosed and treated in our hospital from August 2019 to June 2020 were selected as the research objects.The children were divided into control group and observation group by random number table method,with 37 cases in each group.The control group was treated with BiPAP,and the observation group was treated with caffeine citrate combined with BiPAP.The therapeutic effects of the two groups were compared.Results After treatment,the air way resistance(RAW)and peak inflation pressure(PIP)in the observation group were lower than those in the control group,and the pulmonary static compliance(Cst)was greater than that in the control group(P<0.05).After treatment,the levels of malondialdehyde(MDA)and endothelin-1(ET-1)in the observation group were lower than those in the control group,and the levels of superoxide dismutase(SOD),total antioxidant capacity(T-AOC)and nitric oxide(NO)were higher than those in the control group(P<0.05).The auxiliary ventilation time,oxygen supply time and hospitalization time of the observation group were shorter than those of the control group,and the number of apneas during treatment was less than that of the control group(P<0.05).Conclusion Caffeine citrate combined with BiPAP in the treatment of NRDS has better effect.

关 键 词：枸橼酸咖啡因 新生儿呼吸窘迫综合征 双水平正压通气 

分 类 号：R722.1[医药卫生—儿科]