ABCA1在系统性红斑狼疮合并心血管疾病发病机制中的研究进展  

Advances in ABCA1 in the pathogenesis of systemic lupus erythematosus complicated with cardiovascular disease

作　　者：寇艳婷 张旋(综述) 原江水(审校)[2] KOU Yanting;ZHANG Xuan;YUAN Jiangshui(Dalian Medical University,Dalian,Liaoning 116044,China;Department of Clinical Laboratory,Qingdao Municipal Hospital,Qingdao,Shandong 266071,China;Qingdao Health School,Qingdao,Shandong 266000,China)

机构地区：[1]大连医科大学,辽宁大连116044 [2]青岛市市立医院检验科,山东青岛266071 [3]山东省青岛卫生学校,山东青岛266000

出　　处：《重庆医学》2023年第17期2676-2681,共6页Chongqing medicine

基　　金：国家自然科学基金青年基金项目(31800680)。

摘　　要：系统性红斑狼疮(SLE)是一种自身免疫性疾病,其致死率以双峰模式为特征,早期峰值为狼疮活动,后期峰值主要为SLE相关的心血管疾病。SLE患者并发动脉粥样硬化、缺血性卒中和心肌梗死等疾病与患者的血脂异常、全身炎症及免疫因素有密切联系。ATP结合盒转运蛋白A1(ABCA1)是一种以ATP为能源的整合膜蛋白,其功能是促进细胞内胆固醇和磷脂外流。ABCA1介导的胆固醇和磷脂外流,与SLE相关的心血管疾病密切相关,其表达水平在SLE患者加速发生的动脉粥样硬化中起重要作用,为SLE相关的心血管疾病带来了新的研究方向。该文主要对ABCA1介导的脂质外流及其在SLE相关的心血管疾病发病机制中的作用做一综述。Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by a bimodal pattern of mortality,with an early peak in lupus activity and a later peak in SLE-related cardiovascular disease(SLE-CVD).Diseases such as atherosclerosis,ischemic stroke and myocardial infarction in SLE patients are closely related to dyslipidemia,systemic inflammation and immune factors.ATP binding cassette transporter protein A1(ABCA1)is an ATP-derived integral membrane protein whose function is to promote the outflow of cholesterol and phospholipids from cells.The outflow of cholesterol and phospholipids mediated by ABCA1 is closely related to SLE-related cardiovascular diseases,and its expression level plays an important role in accelerating atherosclerosis in SLE patients,which brings a new research direction for SLE-CVD.This article mainly reviews the lipid outflow mediated by ABCA1 and its role in the pathogenesis of SLE-CVD.

关 键 词：ATP结合盒转运蛋白A1 胆固醇逆向转运 系统性红斑狼疮 心血管疾病 综述 

分 类 号：R758[医药卫生—皮肤病学与性病学]