中医药基于JAK/STAT信号通路治疗糖尿病肾病研究概述  

Overview of TCM in the Treatment of Diabetic Nephropathy Based on JAK/STAT Signaling Pathway

作　　者：李迈 米登海 杨丽霞[2] 李次艳 LI Mai;MI Denghai;YANG Lixia;LI Ciyan(Gansu University of TCM,Lanzhou 730000,China;Gansu Province Academy of TCM,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医药研究院,甘肃兰州730050

出　　处：《西部中医药》2023年第9期157-161,共5页Western Journal of Traditional Chinese Medicine

基　　金：省属科研院所创新能力建设专项(20JR10RA432)。

摘　　要：就酪氨酸蛋白激酶/信号转导因子和转录活化因子(janus kinase/signal transducer and activator of transcription,JAK/STAT)信号通路对糖尿病肾病(diabetic nephropathy,DN)的作用机制,以及针对此通路的中医药相关研究进行综述,指出DN是糖尿病(diabetes mellitus,DM)最严重的慢性并发症之一,也是威胁现代人类健康的重要疾病之一,对患者的日常生活造成了诸多不利影响,但DN确切的发生发展机制尚未明确,近年来JAK/STAT信号通路对DN的调控作用已成为研究热点。The paper sums up the mechanism of JAK/STAT signaling pathway in diabetic nephropathy(DN)and TCM related studies on this pathway,it is pointed out that DN is one of the most serious chronic complications of diabetes,and also one of the important diseases threatening modern human health,which has caused many adverse effects on patients'daily life,but the exact mechanism of the occurrence and development of DN has not been clearly elaborated,the regulatory role of JAK/STAT signaling pathway in DN has been the hot topic in recent years.

关 键 词：糖尿病肾病 JAK/STAT信号通路 中医药 综述 

分 类 号：R256.5[医药卫生—中医内科学]