Sodium-glucose cotransporter-2 inhibitor use in kidney transplant recipients  

作　　者：Pavithra Ramakrishnan Neetika Garg Samantha Pabich Didier A Mandelbrot Kurtis J Swanson 

机构地区：[1]Department of Medicine,University of Minnesota,Minneapolis,MN 55455,United States [2]Department of Medicine,University of Wisconsin School of Medicine and Public Health,Madison,WI 53705,United States

出　　处：《World Journal of Transplantation》2023年第5期239-249,共11页世界移植杂志

摘　　要：Sodium-glucose cotransporter-2 inhibitors(SGLT2i)are novel oral hypoglycemic agents garnering much attention for their substantial benefits.These recent data have positioned SGLT2i at the forefront of diabetic chronic kidney disease(CKD)and heart failure management.SGLT2i use post-kidney transplant is an emerging area of research.Highlights from this mini review include the following:Empagliflozin is the most prescribed SGLT2i in kidney transplant recipients(KTRs),median time from transplant to initiation was 3 years(range:0.88-9.6 years).Median baseline estimated glomerular filtration rate(eGFR)was 66.7 mL/min/1.73 m2(range:50.4-75.8).Median glycohemoglobin(HgbA1c)at initiation was 7.7%(range:6.9-9.3).SGLT2i were demonstrated to be effective short-term impacting HgbA1c,eGFR,hemoglobin/hematocrit,serum uric acid,and serum magnesium levels.They are shown to be safe in KTRs with low rates of infections,hypoglycemia,euglycemic diabetic ketoacidosis,and stable tacrolimus levels.More data is needed to demonstrate long-term outcomes.SGLT2i appear to be safe,effective medications for select KTRs.Our present literature,though limited,is founded on precedent robust research in CKD patients with diabetes.Concurrent research/utilization of SGLT2i is vital to not only identify long-term patient,graft and cardiovascular outcomes of these agents,but also to augment management in KTRs.

关 键 词：Sodium glucose cotransporter-2 Sodium glucose cotransporter-2 inhibitor Kidney transplantation DIABETES Post-transplant diabetes mellitus New onset diabetes after transplant 

分 类 号：R69[医药卫生—泌尿科学]