Heat shock protein 70-2 and tumor necrosis factor-α gene polymorphisms in Chinese children with Henoch- Schönlein purpura  

作　　者：Gui-Xia Ding Chen-Hu Wang Ruo-Chen Che Wan-Zhen Guan Yang-Gang Yuan Min Su Ai-Hua Zhang Song-Ming Huang 

机构地区：[1]Department of Nephrology,Nanjing Children's Hospital,Nanjing Medical University,Nanjing,China [2]Institute of Pediatrics,Nanjing Medical University,Nanjing,China

出　　处：《World Journal of Pediatrics》2016年第1期49-54,共6页世界儿科杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(No.81170635,81270785).

摘　　要：Background:Henoch-Schönlein purpura(HSP)or IgAassociated vasculitis is related to immune disturbances.Polymorphisms of the heat shock protein 70-2 gene(HSP70-2)and the tumor necrosis factor-αgene(TNF-α)are known to be associated with immune diseases.The purpose of this study was to investigate the likely association of HSP70-2(+1267A/G)and TNF-α(+308A/G)gene polymorphisms with HSP in children.Methods:The polymerase chain reaction restriction fragment length polymorphism method was used to detect the HSP70-2 and TNF-αpolymorphisms in 205 cases of children with HSP and 53 controls;and the association of these polymorphisms with HSP and HSP nephritis(HSPN)was analyzed.Results:The G/G genotypic frequencies at the+1267A/G position of HSP70-2 in the HSP group(22.9%)were signifi cantly higher than those in the healthy control group(9.4%)(χ^(2)=4.764,P<0.05).The frequencies of the A/A,A/G and G/G genotypes of HSP70-2 in patients in the nephritis-free group and the HSPN group showed no statistically significant difference.The A/A genotype frequency at the+308G/A position of TNF-αin the HSP group was 8.3%,which was higher than that in the control group(χ^(2)=6.447,P<0.05).The A allele frequency of TNF-αin the HSP group was higher than that in the control group,with a statistically significant difference(χ^(2)=7.241,P<0.05).Conclusions:The HSP70-2(+1267A/G)and TNF-α(+308G/A)gene polymorphisms were associated with HSP in children.The G/G homozygosity of HSP70-2 and the A/A homozygosity of TNF-αmay be genetic predisposing factors for HSP.

关 键 词：gene polymorphism heat shock protein 70-2 Henoch-Schönlein purpura Henoch-Schönlein purpura nephritis tumor necrosis factor-α 

分 类 号：R72[医药卫生—儿科]