益生菌辅助治疗对肝硬化患者肝功能和肠道菌群影响的Meta分析  

Meta-analysis of the effects of assisted probiotic therapy on liver function and intestinal flora in patients with cirrhosis

作　　者：安雯静 陈婷[2] 苏艳 王海平[3] 张磊[2] 李汛[2] An Wenjing;Chen Ting;Su Yan;Wang Haiping;Zhang Lei;Li Xun(School of Nursing,Lanzhou University,Lanzhou 730000,China;Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou 730000,China;Key Laboratory of Biological Therapy and Regenerative Medicine Transformation of Gansu Province,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学护理学院,甘肃兰州730000 [2]兰州大学第一医院普外科,甘肃兰州730000 [3]兰州大学第一医院、甘肃省生物治疗与再生医学重点实验室,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2023年第7期39-49,共11页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金面上资助项目(31770536)。

摘　　要：目的通过整合相关随机对照试验,探讨在常规治疗基础上增加益生菌辅助治疗对肝硬化患者肝功能和肠道菌群的影响,为临床肝硬化的治疗提供参考依据。方法检索中国生物医学文献服务系统、中国知识基础设施工程、Web of Science、Cochrane Library等数据库中有关采用益生菌辅助治疗肝硬化的文献,检索时间建库至2022年9月30日。2名研究者独立筛选文献并评估偏倚风险,采用RevMan 5.3分析数据。结果最终纳入48篇文献研究,中文43篇,英文5篇。Meta分析结果显示血浆内毒素:MD=-0.11,95%CI:[-0.13,-0.08];谷丙转氨酶:MD=-9.62,95%CI:[-13.11,-6.12];谷草转氨酶:MD=-9.74,95%CI:[-11.74,-7.75];总胆红素:MD=-6.68,95%CI:[-9.60,-3.75];白蛋白:MD=1.50,95%CI:[0.63,2.36];乳杆菌:MD=2.22,95%CI:[1.17,3.27];双歧杆菌:MD=2.67,95%CI:[1.89,3.46];肠球菌:MD=0.97,95%CI:[0.13,1.80];酵母样真菌:MD=-0.81,95%CI:[-1.35,-0.28]。结论益生菌治疗能够改善肝硬化患者肝功能,调节肠道菌群,减轻肠道屏障损害。Objective Through integrating relevant randomized controlled trials to dicuss the effects of adding probiotic-assisted therapy on liver function and intestinal flora in patients with cirrhosis on the basis of conventional treatment,and to provide evidence for clinical treatment and nursing of cirrhosis.Method Literature related to liver cirrhosis and probiotics was searched in Chinese and foreign databases such as SinoMed,China National Knowledge Infrastructure,Web of Science and the Cochrane Library.The search period was from the establishment of the databases to September 30,2022.Two researchers independently screened the literature and assessed the risk of bias.The data were analyzed using RevMan 5.3.Results 48 studies were covered,including 43 in Chinese and 5 in English.Meta-analysis results showed that for endotoxin:MD=-0.11,95%CI:[-0.13,-0.08],alanine aminotransferase:MD=-9.62,95%CI:[-13.11,-6.12],aspertate aminotransferase:MD=-9.74,95%CI:[-11.74,-7.75],total bilirubin:MD=-6.68,95%CI:[-9.60,-3.75],albumin:MD=1.50,95%CI:[0.63,2.36],Lactobacillus:MD=2.22,95%CI:[1.17,3.27],Bifidobacterium:MD=2.67,95%CI:[1.89,3.46],Enterococcus:MD=0.97,95%CI:[0.13,1.80],and yeast-like fungi:MD=-0.81,95%CI:[-1.35,-0.28].Conclusion Probiotics can improve liver function,regulate intestinal flora and reduce intestinal barrier damage in patients with cirrhosis.

关 键 词：益生菌 肝硬化 肝功能 肠道菌群 META分析 

分 类 号：R473.6[医药卫生—护理学]