A Formal Synthesis of Betamethasone  

作　　者：Shasha Wang Yong Shi Weisheng Tian 

机构地区：[1]CAS Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2015年第6期637-642,共6页中国化学（英文版）

摘　　要：A formal synthesis of betamethasone from 5α-pregnane-3β,16β,20S-triol is described.Key transformations are a bromination-acetylation of triol,an SN2 reaction of the resulting C16α-bromide with dimethylcopperlithium to get the required C16β-methyl group,and a double hydroxylation to prepare the dihydroxyacetone side chain.

关 键 词：BETAMETHASONE pregnanetriol formal synthesis C16β-alkyl group double epoxidation 

分 类 号：O62[理学—有机化学]