An Efficient Synthesis of(+)-Subersic Acid  

作　　者：Jing Wang Peiqiang Wang Jue Li Peiying Wu Jiangmeng Ren Bubing Zeng 

机构地区：[1]Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China [2]Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China [3]School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Chinese Journal of Chemistry》2015年第6期679-682,共4页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21302053);Science and Technology Commission of Shanghai Mu-nicipality(No.14DZ1900102);the Fundamental Research Funds for the Central University(No.WY1113007).

摘　　要：This paper describes a concise and practical route to(+)-subersic acid from naturally occurring(−)-Sclareol in 7 steps.The key step of this route relied on the cross coupling of the diterpene with the arene fragment using the arylation of allylic acetate followed byβ-acetoxy elimination type Heck reaction.

关 键 词：(+)-subersic acid (−)-Sclareol cross coupling Heck reaction 

分 类 号：O62[理学—有机化学]