含三苯胺结构单元的荧光探针用于选择性检测草酰氯和光气  

Fluorescent Probe Containing Triphenylamine Structural Unit for Selective Detection of Oxalyl Chloride and Phosgene

作　　者：程轲 李盛菘 王雪菲 王晓军 郑永超 CHENG Ke;LI Shengsong;WANG Xuefei;WANG Xiaojun;ZHENG Yongchao(School of Chemistry and Materials Science,Jiangsu Normal University,Xuzhou 221116,China;State Key Laboratory of NBC Protection for Civilian,Beijing 102205,China)

机构地区：[1]江苏师范大学化学与材料科学学院,江苏徐州221116 [2]国民核生化灾害防护国家重点实验室,北京102205

出　　处：《防化研究》2023年第1期25-32,共8页CBRN DEFENSE

基　　金：国家自然科学基金项目(21906182)。

摘　　要：草酰氯和光气被广泛用于各种有机中间体的生产,由于其具有较高的毒性,为确保工作环境和公共场所安全,需要开发便捷可靠的检测方法。该项研究将邻苯二胺作为反应活性位点与三苯胺荧光团耦合,设计、合成了一种基于分子内电荷转移(Intramolecular Charge Transfer,ICT)的荧光探针(标记为DATPA)用于同时检测草酰氯和光气,其在溶液中对草酰氯和光气的检测限分别为70 nM和5.5μM。该探针分子在神经性毒剂模拟物氯磷酸二乙酯和各种酰氯类化合物的抗干扰性研究中对草酰氯和光气表现出优异的选择性。在此基础上,通过简单的方式制备了一种基于DATPA的便携试纸条并成功用于检测气相中的草酰氯和光气。Oxalyl chloride and phosgene are widely used in the production of various organic intermediates.Because of their high toxicity,it is imperative to develop a convenient and reliable detection method in order to ensure the safety of working environment and public places.In this research,by coupling o-phenylenediamine(OPD)with triphenylamine fluorophore as the reactive site,an Intramolecular Charge Transfer(ICT)based fluorescent probe(denoted by DATPA)was designed and synthesized for the simultaneous detection of oxalyl chloride and phosgene.The detection limits of oxalyl chloride and phosgene in solution were 70 nM and 5.5μM,respectively.The probe molecule showed an excellent selectivity to oxalyl chloride and phosgene in the study of interference resistance of nerve agent simulant diethyl chlorophosphate and various acyl chloride compounds.On this basis,a portable test strip based on DATPA was prepared in a simple way and successfully used to detect oxalyl chloride and phosgene in the gas phase.

关 键 词：荧光探针 草酰氯 光气 三苯胺 分子内电荷转移 

分 类 号：O621.2[理学—有机化学]