妊娠期糖尿病患者胎盘FGL2凝血酶原酶在滋养细胞的表达及其意义分析  

Expression and significance of placental FGL2 prothrombin in trophoblasts of patients with gestational diabetes mellitus

作　　者：张丽武[1] 覃纬 王丽[1] 黄春燕[1] 石伟红 廖丽云 吴爽 Zhang Liwu;Qin Wei;Wang Li;Huang Chunyan;Shi Weihong;Liao Liyun;Wu Shuang(Department of Obstetrics and Gynecology,Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guilin 541002,China)

机构地区：[1]广西壮族自治区南溪山医院妇产科,桂林541002

出　　处：《中华生物医学工程杂志》2023年第2期168-173,共6页Chinese Journal of Biomedical Engineering

基　　金：2021年广西壮族自治区医疗卫生重点(培育)学科建设项目;桂林市科学研究与技术开发计划项目(2020011206-2)

摘　　要：目的探讨妊娠期糖尿病(GDM)患者胎盘滋养细胞纤维蛋白原样蛋白2(FGL2)凝血酶原酶的表达及其意义分析。方法选取2020年11月至2022年1月在广西壮族自治区南溪山医院妇产科就诊的GDM患者100例作为观察组,同时选取正常孕妇100例作为对照组,比较两组FGL2凝血酶原酶mRNA、蛋白表达,同时分析观察组有和无不良妊娠结局患者临床资料、FGL2凝血酶原酶mRNA、蛋白表达差异。结果观察组FGL2凝血酶原酶mRNA、蛋白表达分别为(1.03±0.31)和(0.97±0.22),明显高于对照组(P<0.05)。观察组有和无不良妊娠结局患者年龄、孕期体质量指数(BMI)和不良孕产史比较差异有统计学意义(P<0.05);观察组有不良妊娠结局患者FGL2凝血酶原酶mRNA、蛋白表达、空腹血糖(FBG)和胰岛素抵抗指数(HOMA-IR)分别为(1.34±0.29)、(1.21±0.26)、(7.25±0.87)mmol/L和(1.95±0.30),明显高于无不良妊娠结局患者(P<0.05)。FGL2凝血酶原酶mRNA、蛋白表达与FBG、HOMA-IR呈正相关(P<0.05)。Logistic回归分析显示,年龄、孕期BMI、FGL2凝血酶原酶mRNA、蛋白表达是GDM患者不良妊娠结局的影响因素(P<0.05)。结论GDM患者胎盘滋养细胞FGL2凝血酶原酶mRNA、蛋白表达明显上调,与患者胰岛素抵抗、不良妊娠结局有关,值得进一步研究。Objective To investigate the expression and significance of fibrinogen like protein 2(FGL2)prothrombin in placental trophoblasts of patients with gestational diabetes mellitus(GDM).Methods A total of 100 GDM patients who stayed at Department of Obstetrics and Gynecology of Nanxishan Hospital of Guangxi Zhuang Autonomous Region between November 2020 and January 2022 were included as the study group,and a contemporary cohort of 100 normal pregnant women as the control group.The two groups were compared for the mRNA and protein expression of FGL2 prothrombin.The differences in clinical data,mRNA and protein expression of FGL2 prothrombin were also analyzed between patients with and without adverse pregnancy outcomes in the study group.Results The expression levels of FGL2 prothrombin mRNA and protein in the study group were(1.03±0.31)and(0.97±0.22)respectively,which were significantly higher than those in the control group(P<0.05).There were statistically significant differences in the age,body mass index and history of adverse pregnancy between patients with and without adverse pregnancy outcomes in the study group(P<0.05).The expression of FGL2 prothrombin mRNA and protein,fasting blood glucose and insulin resistance index(HOMA-IR)in patients with adverse pregnancy outcomes in the study group were(1.34±0.29),(1.21±0.26),(7.25±0.87)mmol/L and(1.95±0.30),which were significantly higher than those in patients without adverse pregnancy outcomes(P<0.05).The expression of FGL2 prothrombin mRNA and protein was positively correlated with fasting blood glucose and HOMA-IR(P<0.05).Logistic regression analysis showed that age,body mass index during pregnancy,and mRNA and protein expression of FGL2 prothrombin were influencing factors of adverse pregnancy outcomes in GDM patients(P<0.05).Conclusion The mRNA and protein expression of FGL2 prothrombin in placental trophoblasts of patients with GDM is significantly up-regulated and associated with insulin resistance and adverse pregnancy outcomes,rendering further study wa

关 键 词：妊娠期糖尿病 胎盘 滋养细胞 纤维蛋白原样蛋白2凝血酶原酶 临床意义 

分 类 号：R714.256[医药卫生—妇产科学]