老年髋关节置换术患者血清黏附分子-1、视锥蛋白样蛋白-1水平变化及与认知功能的关系  

Changes of serum soluble intercellular adhesion molecule-1 and visinin-like protein-1 levels in elderly patients undergoing hip replacement and their relationship with cognitive function

作　　者：韩杰[1] 张鹏[1] 斯焱[1] 毕梦娜[1] 张上上[1] 马邹 王一臣 Han Jie;Zhang Peng;Si Yan;Bi Mengna;Zhang Shangshang;Ma Zou;Wang Yichen(Department 1 of geriatric orthopedics,Sichuan Orthopedic Hospital,Chengdu 610041,China)

机构地区：[1]四川省骨科医院老年骨科1,成都610041

出　　处：《中华生物医学工程杂志》2023年第2期197-200,共4页Chinese Journal of Biomedical Engineering

基　　金：四川省科技计划项目(2022 YFS0387)。

摘　　要：探讨老年髋关节置换术患者血清可溶性细胞间黏附分子-1(sICAM-1)、视锥蛋白样蛋白-1(VILIP-1)水平变化及与认知功能的关系。研究显示认知障碍组患者血清sICAM-1、VILIP-1水平高于认知正常组,MMSE评分低于认知正常组(P<0.05)。血清sICAM-1、VILIP-1均为影响老年髋关节置换术患者发生认知功能障碍的相关因素(P<0.05)。To investigate the changes of serum soluble intercellular adhesion molecule-1(sICAM-1),visual cone like protein-1(VILIP-1)and their relationship with cognitive function in elderly patients undergoing hip replacement.Research show:serum sICAM-1 and VILIP-1 were the related factors affecting cognitive dysfunction in elderly patients with hip replacement(P<0.05).The levels of sICAM-1 and VILIP-1 in serum of elderly patients with hip arthroplasty increased,and there was a certain relationship between them and their cognitive function.

关 键 词：髋关节置换术 老年人 血管性痴呆 认知功能障碍 认知功能 

分 类 号：R687.4[医药卫生—骨科学]