Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo,Tibet,China:A prospective cross-sectional,school-based study  

作　　者：Ke-Xin Sun Yong-Guo Xiang Tong Zhang Sheng-Lan Yi Jiu-Yi Xia Xin Yang Shi-Jie Zheng Yan Ji Wen-Juan Wan Ke Hu 

机构地区：[1]Department of Ophthalmology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China [2]The First Affiliated Hospital of Chongqing Medical University,Chongqing Medical University,Chongqing 400016,China

出　　处：《World Journal of Clinical Cases》2023年第23期5479-5493,共15页世界临床病例杂志

基　　金：Supported by the National Natural Science Foundation of China,No.81870650,No.81570832,and No.81300794;Science and Technology Program Chongqing,China,No.2018GDRC008.

摘　　要：BACKGROUND Optical coherence tomography angiography(OCTA)is a new and reliable machine used to evaluate retinal structure and macular perfusion in children.The use of OCTA under bad condition such as high altitude,low atmospheric oxygen,and low humidity,in children is rarely.AIM To quantify the macular micro-vasculature in healthy children of various ages using OCTA in Qamdo.METHODS Design:Prospective cross-sectional,school-based study.Three hundred and fortyseven normal students from 9 schools in 4 different areas in Qamdo were included.OCTA was performed on a 3 mm×3 mm area centered on the macular region and macular cube 512×128 showed details in macular.Early treatment of diabetic retinopathy study Vessel Flow Density(VD)of the macular central vascular plexus density(CVD),inner vascular plexus density(IVD),full vascular plexus density(FVD),and the size of the foveal avascular zone(FAZ)were measured.All these results corrected by t/s=3.382×0.01306×(axial length-1.82).The differences were compared among various ages,sexes and living environments.RESULTS The mean FAZ area in all eyes was 0.27 mm^(2)±0.12 mm^(2).The mean foveal thickness(MFT)in the macular cube was 227.64μm±23.51μm.Compared with girls,boys had a lager FAZ(P=0.0029).Among the different age groups,MFT(P<0.001)and FVD(P<0.0001),IVD(P<0.0001),and CVD(P=0.0050)increased with age.FAZ areas were not correlated with age(P=0.8853)or others(MFT,area).CONCLUSION OCTA can use to evaluate macular perfusion in children.Our data bridge the gap between structural OCT and perfusion density in children in high altitude.Even though these were not a longitudinal study,it may provide us with hints about retina development during puberty and clinical implications of OCTA in children.

关 键 词：Optical coherence tomography-angiography Qamdo Foveal avascular zone area Vessel flow density TEENAGER 

分 类 号：R685[医药卫生—骨科学]