Relevant detection indicator of prethrombotic state in patients with primary hypertension  

作　　者：Jie Luo Tuo Yang Lan Ding Jian-Hui Xiong Teng Ying Fen Xu 

机构地区：[1]Medical Technology Department,Jiangxi Medical College,Shangrao 334000,Jiangxi Province,China [2]Inspection Department,Guangdong Zhanjiang Health School Labor Union,Zhanjiang 524094,Guangzhou Province,China [3]Department of Medical Technology,Jiangxi Medical College,Shangrao 334000,Jiangxi Province,China [4]Department of Cardiology,The First Affiliated Hospital of Jiangxi Medical College,Shangrao 334000,Jiangxi Province,China

出　　处：《World Journal of Clinical Cases》2023年第24期5678-5691,共14页世界临床病例杂志

基　　金：Supported by The Science and Technology Research Project of Jiangxi Provincial Department of Education,No.GJJ2205812.

摘　　要：BACKGROUND Hypertension is a common chronic disease that affects many people worldwide.Only a few reports related to the exploration of relevant indicators of the prethrombotic state in patients with primary hypertension(PH)in clinical settings were available.AIM To detect prethrombotic state-related indicators in patients with PH and analyze their differences in different patient populations to provide a laboratory basis for the clinical prevention and control of hypertensive thrombotic diseases.METHODS The general data of patients with PH who attended the Department of Cardiovascular Medicine,The First Affiliated Hospital of Jiangxi Medical College,from January 2022 to December 2022 were collected retrospectively.The patients were divided into three groups of 40 patients each according to the Grade of PH:Grade 1,Grade 2,and Grade 3 hypertension experimental group.The baseline data of 40 volunteers,who underwent physical examination in our hospital but were not diagnosed with PH during the same period,were included in the control group.The relevant indicators of prethrombotic state of the participants were compared,and mainly included inflammation-related indicators,hemorheology-related indicators,and coagulation function related indicators.The relationship between the aforementioned indicators and the progression of PH was analyzed.RESULTS No significant differences were observed in age,sex,diabetes mellitus,smoking history,drinking history,body mass index,New York Heart Association functional classification,or the course of hypertension among the four groups(P>0.05).The expressions of high-sensitivity C-reactive protein(hs-CRP),thrombomodulin(TM),hematocrit(Hct),erythrocyte sedimentation rate(ESR),P-selectin on platelet surface(CD62P),and fibrinogen(FIB)in the control group were<Grade 1 hypertension group<Grade 2 hypertension group<Grade 3 hypertension group,and the expressions of platelet(PLT),activated partial thromboplastin time(APTT),prothrombin(PT),and plasma thrombin time(TT)in the control group was>Grad

关 键 词：Primary hypertension Prethrombotic state HEMATOCRIT P-selectin on platelet surface Activated partial thromboplastin time Erythrocyte sedimentation rate 

分 类 号：R544.1[医药卫生—心血管疾病] R739.4[医药卫生—内科学]