洞穴探险与洞穴病-组织胞浆菌病  

Cave expedition and histoplasmosis, a kind of cave disease

作　　者：孙承航[1] SUN Chenghang(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院&北京协和医学院医药生物技术研究所,北京100050

出　　处：《中国岩溶》2023年第3期616-626,共11页Carsologica Sinica

基　　金：中国医学科学院医学与健康科技创新工程项目(CIFMS2021-I2M-1-028)。

摘　　要：文章介绍了一种与洞穴探险关系密切的深部真菌感染性疾病-组织胞浆菌病,回顾了组织胞浆菌病及其病原真菌,荚膜组织胞浆菌的发现、洞穴病的提出、洞穴中感染源和传播途径的研究历程。结合世界及我国洞穴中组织胞浆菌病爆发的实例,介绍了预防组织胞浆菌病的相关知识,并为安全地开展洞穴探险提供了建议。Histoplasmosis is an invasive fungal infection,which might breakout among people who are exposed to the Histoplasma capsulatum,usually,Histoplasma capsulatum var.capsulatum.This disease is an occupational disease of cave explorers,but many cavers or cave managers have never learned,or known very little about it.In order to popularize the disease and its prevention among karst cave geologists,cave explorers and managers,this review introduced histoplasmosis through seven sections following the introduction of histoplasmosis as one of the threats faced by cavers during cave survey in the preface.The first section retrospect research history about the discovery of histoplasmosis and its pathogenic fungus,Histoplasma capsulatum,on the basis of papers published by US scientists,Samuel T.Darling in 1906 and 1908,William DeMonbreun in 1934 and 1939,as well as Chester W.Emmons in 1947 and 1948.The second section introduced definition of cave sickness and investigation on the source of infection in cave.The third section summarized the research evidence how bat spread Histoplasma capsulatum to caver,some important papers published in Science by Martha H.Shacklette in 1962 and Marinkelle C J in 1965 were cited in the section.The fourth and fifth section discussed geographical distribution of histoplasmosis in the world and in China,respectively.Furthermore,in the fifth section,the analysis of histoplasmosis cases in China from three different groups in different period, such as case statistics of 1990-2011 by Pan Bo from Shanghai Changzheng Hospital, case statisticsof 2001-2014 by Yu Jie from Huashan Hospital and case statistics of 2001-2019 by LYU Xin from Xiangya Hospital,all data showed Yunnan, Hubei, Hunan, Chongqing, Jiangsu, Guangdong, Sichuan, Zhejiang,Shanghai,Guangxi, mostcases came from in China. Meanwhile, in the fifth section, the earliest histoplasmosis cases in China in 1950s werelooked back. On the basis of histoplasmosis outbreaks in China and the World, the sixth section summarized theknowledge on how to p

关 键 词：组织胞浆菌病 荚膜组织胞浆菌 洞穴 真菌 蝙蝠 

分 类 号：R519[医药卫生—内科学]