Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair?  

作　　者：Ricardo Gómez-Oliva Pedro Nunez-Abades Carmen Castro 

机构地区：[1]Área de Fisiología,Facultad de Medicina Universidad de Cádiz,Cadiz,Spain [2]Instituto de Investigación e Innovación en Biomedicina de Cádiz,Cadiz,Spain [3]Departamento de Fisiología,Facultad de Farmacia,Universidad de Sevilla,Seville,Spain

出　　处：《Neural Regeneration Research》2024年第5期935-936,共2页中国神经再生研究（英文版）

基　　金：supported by the Spanish Ministerio de Ciencia, Innovación y Universidades, No. RTI2018-099908-B-C21 (to CC);the Consejería de Economía, Conocimiento, Empresas y Universidades, No. FEDER-UCA18-106647 (to CC);the Consejería de Salud y Familias 80% co-financed by EDRF ITI regional funds, No. ITICadiz-0042-2019 (to CC).

摘　　要：The existence of neural stem cells(NSC)in specific areas of the adult mammalian brain leads to the generation of new neurons involved in homeostatic mechanisms.This is the case of the NSC of the subventricular zone(SVZ)that produces olfactory bulb(OB)neurons.These neurons integrate into circuits to modulate sensory information and participate in olfactory processing(Bragado Alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSC of the SVZ.First,the activation of quiescent NSC is necessary to produce intermediate transit amplifying progenitors(TAP),which will generate neuroblasts.The latter are cells that maintain a proliferative phenotype while in an immature phase.However,once they initiate migration toward the OB,they progressively undergo their differentiation into neurons(Kjell et al.,2020).

关 键 词：VENTRICULAR MAINTAIN 

分 类 号：Q189[生物学—神经生物学]