玉屏风颗粒联合脾氨肽辅治小儿支原体肺炎对血清炎性因子及免疫功能的影响  

Effects of Yupingfeng(玉屏风)Combined with Spleen Aminopeptide on Lung Function,Serum Inflammatory Factors and Immune Function in Children with Mycoplasma Pneumonia

作　　者：王若愚 孙华君 王毓国[3] WANG Ruoyu;SUN Huajun;WANG Yuguo(Tengzhou Central Peoples Hospital,Tengzhou 277500,Shandong,China;Zaozhuang Vocational College of Science and Technology,Tengzhou 277500,Shandong,China;The Sixth Medical Center,PLA General Hospital,Beijing 100048,China)

机构地区：[1]滕州市中心人民医院,山东滕州277500 [2]枣庄科技职业学院,山东滕州277500 [3]解放军总医院第六医学中心,北京100048

出　　处：《中华中医药学刊》2023年第8期122-125,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项(2019ZX77569183);解放军总医院第六医学中心创新培育基金项目(CXPY202114)。

摘　　要：目的 探讨玉屏风颗粒联合脾氨肽辅治小儿支原体肺炎对血清炎性因子及免疫功能的影响。方法 选取100例肺炎患儿,随机分为对照组与观察组,每组50例,对照组常规抗感染及对症治疗,观察组在对照组治疗基础上给予玉屏风颗粒联合脾氨肽口服冻干粉辅助治疗,疗程10 d,观察两组症状及体征、血清炎性因子及免疫功能变化情况。结果 观察组体温恢复正常时间、咳喘消失时间、肺部罗音消失时间明显短于对照组(P<0.05);两组治疗前血清超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)、白介素6(interleukin 6,IL-6)、白介素10(interleukin 10,IL-10)和肿瘤坏死因子α(tumor necrosis factor α,TNF-α)比较差异无统计学意义(P>0.05),治疗后较治疗前下降(P<0.05),且观察组下降程度大于对照组(P<0.05);两组治疗前CD_(4)、CD_(4)/CD_(8)、免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白A(immunoglobulin A,IgA)比较差异无统计学意义(P>0.05),CD_(4)、CD_(4)/CD_(8)、IgM、IgG、IgA治疗后较治疗前升高(P<0.05),且观察组升高程度大于对照组(P<0.05),CD8治疗后较治疗前下降(P<0.05),且观察组下降幅度大于对照组(P<0.05);观察组治疗疗效优于对照组(P<0.05)。结论 玉屏风联合脾氨肽辅治小儿支原体肺炎有助于缩短阳性症状及体征改善时间,抑制炎症反应,调节免疫功能,提高治疗疗效。Objective To investigate the effects of Yupingfeng Granule(玉屏风颗粒) combined with spleen aminopeptide on lung function, serum inflammatory factors and immune function in children with mycoplasma pneumonia. Methods A total of 100 cases children with pneumonia were randomly divided into control group and observation group, the each group contained 50 cases. The control group used routine anti-infection and symptomatic treatment and the observation group was additionally given Yupingfeng Granule combined with Spleen Aminopeptide Oral Lyophilized Powder for adjuvant therapy for 10 d. The changes of symptoms and signs, serum inflammatory factors and immune function were observed. Results The time of body temperature returning to normal, cough and asthma disappearing and pulmonary rales disappearing in the observation group were significantly shorter than those in the control group(P<0.05). There were no significant differences in the serum hypersensitive C-reactive protein(hS-CRP),interleukin 6(IL-6),interleukin 10(IL-10) or tumor necrosis factor α(TNF-α) between the two groups before treatment(P<0.05),and decreased after treatment compared with those before treatment(P<0.05),and the degree of decrease in the observation group was greater than that in the control group(P<0.05). There were no significant differences in the CD_(4),CD_(4)/CD_(8),immunoglobulin M(IgM),immunoglobulin G(IgG) or immunoglobulin A(IgA) between the two groups before treatment(P<0.05). The levels of CD_(4),CD_(4)/CD_(8),IgM,IgG and IgA increased after treatment compared with those before treatment(P<0.05),and the increase degree in the observation group was greater than that in the control group(P<0.05),CD_(8) decreased after treatment compared with that before treatment(P<0.05),and the degree of decrease in the observation group was greater than that in the control group(P<0.05). The therapeutic effect of the observation group was better than that of the control group(P<0.05). Conclusion Treatment of pneumonia in children with Yupingf

关 键 词：玉屏风 脾氨肽 支原体肺炎 炎性因子 免疫功能 

分 类 号：R259.631[医药卫生—中西医结合]