葛根芩连汤内服联合愈疡灌肠方保留灌肠治疗溃疡性结肠炎疗效及对血清LPO与SCD-1表达的影响  

Effect of Gegen Qinlian Decoction(葛根芩连汤)for oral Administration Combined with Yuyang Enema Recipe(愈疡灌肠方)for Retention Enema in Treatment of Ulcerative Colitis and Influence on Expressions of Serum LPO and SCD-1

作　　者：李季[1] 郭玉婷[1] 郭亮[1] 江海[1] 江学良 LI Ji;GUO Yuting;GUO Liang;JIANG Hai;JIANG Xueliang(The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001,Shandong,China)

机构地区：[1]山东中医药大学第二附属医院,山东济南250001

出　　处：《中华中医药学刊》2023年第8期131-134,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2018YFC1705404)。

摘　　要：目的 探讨葛根芩连汤内服联合愈疡灌肠方保留灌肠治疗溃疡性结肠炎的疗效及对血清脂质过氧化物(Lipid peroxide, LPO)和硬脂酰辅酶A脱氢酶(Stearoyl-CoA desaturase1,SCD-1)表达的影响。方法 选取160例溃疡性结肠炎患者,随机分为对照组与观察组,每组80例,对照组给予美沙拉嗪肠溶片口服治疗,观察组采用葛根芩连汤内服联合愈疡灌肠方保留灌肠治疗,疗程3个月。检测治疗前后血清LPO与SCD-1水平,高敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)、肿瘤坏死因子(tumor necrosis factor, TNF-α)、白细胞介素-6(Interleukin-6,IL-6)水平,SCD-1用硬脂酰溶血卵磷脂(硬脂酰-LPC)与油酰溶血卵磷脂(油酰-LPC)比值反映,观察药物不良反应发生情况及评价治疗疗效。结果 两组患者治疗前血清LPO与SCD-1比较差异无统计学意义(P>0.05),治疗后清LPO下降,且观察组治疗后水平低于对照组,治疗后血清SCD-1升高,且观察组治疗后水平高于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前血清hs-CRP、TNF-α、IL-6比较差异无统计学意义(P>0.05),治疗后上述指标水平下降,且观察组治疗后水平低于对照组,比较差异有统计学意义(P<0.05);不良反应发生率对照组为12.00%(10/80),观察组为18.75%(15/80),比较差异无统计学意义(P>0.05);观察组治疗疗效整体优于对照组(P<0.05),观察组治疗总有效率为85.00%(68/80)高于对照组(70.00%,56/80),比较差异有统计学意义(P<0.05)。结论 葛根芩连汤内服联合愈疡灌肠方保留灌肠治疗溃疡性结肠炎疗效肯定,可调节血清LPO与SCD-1的表达,抑制肠道炎症反应,加速肠黏膜愈合,且药物不良反应未明显增加,用药安全。Objective To investigate the effect of Gegen Qinlian Decoction(葛根芩连汤) for oral administration combined with Yuyang Enema Recipe(愈疡灌肠方) for retention enema in the treatment of ulcerative colitis and the influence on the expressions of lipidperoxidation(LPO) and stearoyl-CoA desaturase(SCD-1) in serum. Methods A total of 160 patients with ulcerative colitis were collected and randomly divided into control group and observation group and the each group had 80 cases. The control group was treated with mesalazine enteric-coated tablets orally and the observation group was given Gegen Qinlian Decoction for oral administration combined with Yuyang Enema Recipe for retention enema. The course of treatment was 3 months. The levels of LPO and SCD-1,the levels of high sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α) and interleukin-6(IL-6) in serum were detected before and after treatment. SCD-1 was reflected by the ratio of stearoyl-lysate lecithin(stearoyl-LPC) to oleoyl-lysine(oleoyl-LPC). The occurrence of adverse reactions was observed and the therapeutic effect was evaluated. Results There was no significant difference in LPO,SCD-1,hs-CRP,TNF-α or IL-6 in serum between the two groups before treatment(P<0.05). The levels of LPO,hs-CRP,TNF-α and IL-6 of the two groups decreased after treatment compared with those before treatment(P<0.05). The levels of LPO,hs-CRP,TNF-α and IL-6 in serum of the observation group were lower than those of the control group(P<0.05). The levels of SCD-1 of the two groups increased after treatment compared with those before treatment(P<0.05),and the level of observation group was higher than that of the control group(P<0.05). The incidence of adverse reactions was 12.00%(10/80) in the control group and 18.75%(15/80) in the observation group and there was no statistical significance(P<0.05). The therapeutic effect of the observation group was better than that of the control group(P<0.05). The total effective rate was 85%(68/80),higher than that(70.00%

关 键 词：葛根芩连汤 愈疡灌肠方 保留灌肠 溃疡性结肠炎 脂质过氧化物 硬脂酰辅酶A脱氢酶 

分 类 号：R259.746.2[医药卫生—中西医结合]