热淋清颗粒联合头孢西丁对尿路感染病原学、PCT、IL-6及肝肾功能的影响  

Etiology,Expressions of PCT and IL-6 and Liver and Kidney Function of Patients with Urinary Tract Infection Treated with Relinqing Granules(热淋清颗粒)and Cefoxitin

作　　者：蒋全 程华明 鲍国[1] 苏孟珂 JIANG Quan;CHENG Huaming;BAO Guo;SU Mengke(Anhui Huainan Xinhua Medical Group,Huainan 232052,Anhui,China;Henan Provincial Staff and Workers'Hospital,Zhengzhou 450003,Henan,China)

机构地区：[1]安徽淮南新华医疗集团新华医院,安徽淮南232052 [2]河南省职工医院,河南郑州450003

出　　处：《中华中医药学刊》2023年第8期218-222,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省科技计划项目(222102310138)。

摘　　要：目的 探讨热淋清联合头孢西丁治疗尿路感染患者病原学、降钙素(Procalcitonin, PCT)、白介素-6(Interleukin-6,IL-6)及肝肾功能的表达。方法 采用随机分组法将医院2019年1月-2022年2月收治的82例尿路感染患者分为观察组与对照组,两组各41例。对照组采用头孢西丁治疗,观察组在此基础上联合使用热淋清治疗。观察两组患者治疗前后PCT、C反应蛋白(C-reactive protein, CRP)、肿瘤坏死因子-α(Tumor necrosis factor, TNF-α)和IL-6水平变化。观察两组患者病原菌分布情况。观察两组患者治疗前后尿频、尿痛、血尿等症状评分。观察两组患者直接胆红素(Direct bilirubin, DBIL)、丙氨酸氨基转移酶(Alanine aminotransferase, ALT)、天门冬氨酸转移酶(Aspartate aminotransferase, AST)、血肌酐(Serum creatinine, Scr)、尿素氮(Blood urea nitrogen, BUN)、白蛋白(Blood urea nitrogen, ALB)差异。比较两组患者临床疗效与不良反应发生率。结果 两组治疗前PCT、CRP、TNF-α和IL-6水平差异无统计学意义(P>0.05)。治疗14 d后观察组PCT、CRP、TNF-α和IL-6水平显著低于对照组(P<0.05)。两组患者感染病原菌分布比较差异无统计学意义(P>0.05)。两组患者治疗前尿路感染评分差异无统计学意义(P>0.05)。治疗后观察组尿路感染评分显著低于对照组(P<0.05)。两组患者治疗前DBIL、AST、ALT、Scr、BUN和ALB指标差异无统计学意义(P>0.05)。治疗14 d后观察组DBIL、AST、ALT、Scr、BUN水平显著低于对照组,且ALB显著高于对照组(P<0.05)。观察组总有效率为90.24%(37/41)显著高于对照组(70.73%,29/41)(χ^(2)=4.969,P=0.025)。结论 热淋清联合头孢西丁能有效提高尿路感染患者临床疗效、降低炎症反应和恢复肝肾功能。Objective To observe the etiology,the expressions of procalcitonin(PCT)and interleukin-6(IL-6)and liver and kidney function of patients with urinary tract infection treated with Relinqing Granules(热淋清颗粒)combined with cefoxitin.Methods Eighty-two patients with urinary tract infection department of the hospital from January 2019 to February 2022 were randomly classified into two groups,each with 41 cases.The control group received cefoxitin treatment.Based on this,the observation group received Relinqing Granule.The levels of PCT,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and IL-6 were detected in both groups.The distribution of pathogens was detected,and the clinical symptoms including frequent urination,dysuria and hematuria were scored in all patients.The levels of direct bilirubin(DBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum creatinine(Scr),blood urea nitrogen(BUN)and albumin(ALB)were detected in all patients.The clinical efficacy rate and adverse reaction rate were recorded in both groups.Results Serum levels of PCT,CRP,TNF-αand IL-6 yielded no statistical difference between two groups at the baseline(P<0.05),and the levels of four inflammation factors at post-treatment 14 d in the observation group were lower than those in the control group(P<0.05).The distribution of pathogens demonstrated no statistical difference between two groups(P<0.05).The levels of DBIL,AST,ALT,Scr,BUN and ALB denoted no statistical difference between two groups before treatment(P<0.05).At 14 d after treatment,the observation group had lower levels of DBIL,AST,ALT,Scr and BUN and higher ALB levels than the control group(P<0.05).The total efficacy rate was 90.24%(37/41)in the observation group,which was higher than 70.73%(29/41)in the control group,with statistical difference(χ^(2)=4.969,P=0.025).Conclusion Application of Relinqing Granules combined with cefoxitin in the treatment of urinary tract infection can effectively improve the clinical efficacy,attenuate the inflammation res

关 键 词：热淋清 头孢西丁 尿路感染 尿液病原学 炎症反应 肝肾功能 

分 类 号：R269.913[医药卫生—中西医结合]